| 中文名称: | Norleual | ||||
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| 英文名称: | Norleual | ||||
| 别名: | Norleual (2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-aminohexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid | ||||
| CAS No: | 334994-34-2 | 分子式: | C41H58N8O7 | 分子量: | 774.95 |
| CAS No: | 334994-34-2 | ||||
| 分子式: | C41H58N8O7 | ||||
| 分子量: | 774.95 | ||||
基本信息
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产品编号：N11186 |
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产品名称：Norleual |
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CAS: |
334994-34-2 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
774.95 |
-20℃ |
一个月 |
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化学名： |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内（现配现用） |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
Norleual is an angiotensin IV analog. Norleual is a highly potent HGF/c-MET inhibitor (IC50=3pM). |
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靶点/IC50 |
c-Met/HGFR |
Angiotensin Receptor |
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体外研究 |
Norleual at 20 and 50pM significantly reduces HGF-dependent c-Met and Gab1 phosphorylation. 20pM Norleual dramatically reduces HGF-initiated association between Gab1 and c-Met in HEK293 cells. Norleual markedly attenuates HGFdependent c-Met activation and downstream signaling.Norleual (1pM-1μM;4 days) is able to inhibit HGF-dependent signaling,proliferation, migration, and invasion in multiple cell types at concentrations in the picomolar range in MDCK cellsNorleual at 20 and 50pM significantly reduces HGF-dependent c-Met and Gab1 phosphorylation. 20pM Norleual dramatically reduces HGF-initiated association between Gab1 and c-Met in HEK293 cells. Norleual markedly attenuates HGFdependent c-Met activation and downstream signaling.Norleual (1pM-1μM; 4 days) is able to inhibit HGF-dependent signaling, proliferation, migration, and invasion in multiple cell types at concentrations in the picomolar range in MDCK cells. |
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体内研究 |
Norleual (50μg/kg; intraperitoneal injection; daily; for 2 weeks;C57BL/6mice)suppresses pulmonary colonization by B16-F10 murine melanoma cells. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
