| 中文名称: | 氯谷胺 | ||||
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| 英文名称: | Loxiglumide | ||||
| 别名: | 氯谷胺 CR-1505 | ||||
| CAS No: | 107097-80-3 | 分子式: | C21H30Cl2N2O5 | 分子量: | 461.38 |
| CAS No: | 107097-80-3 | ||||
| 分子式: | C21H30Cl2N2O5 | ||||
| 分子量: | 461.38 | ||||
基本信息
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产品编号： |
L10430 |
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产品名称： |
Loxiglumide |
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CAS: |
107097-80-3 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
461.38 |
-20℃ |
1个月 |
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化学名： |
Pentanoic acid,4-((3,4-dichlorobenzoyl)amino)-5-((3-methoxypropyl)pentylamino)-5-oxo-,(+-)- |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.1674mL |
10.8371mL |
21.6741mL |
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5mM |
0.4335mL |
2.1674mL |
4.3348mL |
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10mM |
0.2167mL |
1.0837mL |
2.1674mL |
生物活性
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产品描述 |
一种缩胆囊素 (CCK-1) 受体拮抗剂。 |
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靶点 |
CCK-1 receptor |
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体内研究 |
The effects of pancreatic rest by oral administration of CCK-1 receptor antagonist Loxiglumide and pancreas stimulation are investigated via endogenous CCK release induced by po protease inhibitor camostat on the recovery of pancreatic secretory function,and biochemical and histological changes of the pancreas after acute hemorrhagic pancreatitis.Oral administration of CCK-1 receptor antagonist Loxiglumide with a dose of 50mg/kg body weight inhibits pancreatic exocrine secretion for more than 12h.Thus,every 12-h administration of Loxiglumide might have completely blocks the effect of endogenously released CCK on the pancreas (pancreatic rest). |
推荐实验方法(仅供参考)
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动物实验: |
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Rats At 24h after induction of acute hemorrhagic pancreatitis,rats are divided into four different treatment groups:standard rat chow (AP-C);standard rat chow with pancreatic rest (AP-R);standard rat chow with pancreatic stimulation (AP-S);and standard rat chow with pancreatic rest,followed by pancreatic stimulation (AP-R/S).Rats in the AP-C group receive 2mL/kg body weight saline orally (po) via an orogastric tube twice daily (09:00 and 21:00h) for 10 d;the AP-R group receive 50mg/kg body weight of CCK-1 receptor antagonist Loxiglumide dissolved in 2mL distilled water po twice daily for 10 d;the AP-S group receive 25mg/kg body weight protease inhibitor Camostat,which is known to stimulate endogenous CCK release,dissolved in 2mL distilled water po twice daily for 10 d;and the AP-R/S group receive 50mg/kg body weight Loxiglumide twice daily for the first 5 d followed by 25mg/kg body weight camostat twice daily for the next 5 d.Rats are fed ad libitum.On day 12 at 24h after the last treatment and overnight fasting,pancreatic exocrine function and histological examination of the pancreas are performed. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
