| 中文名称: | JDTic dihydrochloride | ||||
|---|---|---|---|---|---|
| 英文名称: | JDTic dihydrochloride | ||||
| 别名: | (3R)-1,2,3,4-四氢-7-羟基-N-[(1S)-1-[[(3R,4R)-4-(3-羟基苯基)-3,4-二甲基-1-哌啶基]甲基]-2-甲基丙基]-3-异喹啉甲酰胺盐酸盐 (3R)-7-Hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride | ||||
| CAS No: | 785835-79-2 | 分子式: | C28H41Cl2N3O3 | 分子量: | 538.55 |
| CAS No: | 785835-79-2 | ||||
| 分子式: | C28H41Cl2N3O3 | ||||
| 分子量: | 538.55 | ||||
基本信息
|
产品编号： |
J10084 |
||||
|
产品名称： |
JDTic dihydrochloride |
||||
|
CAS: |
785835-79-2 |
储存条件 |
粉末 |
-20℃ |
四年 |
|
|
|
||||
|
分子式： |
溶于液体 |
-80℃ |
6个月 |
||
|
分子量： |
538.55 |
-20℃ |
1个月 |
||
|
化学名： |
(3R)-7-Hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride |
||||
|
Solubility (25°C)： |
|||||
|
体外:
|
DMSO |
|
|||
|
Ethanol |
|
||||
|
Water |
|
||||
|
体内(现配现用): |
|
||||
|
＜1mg/ml表示微溶或不溶。 |
|||||
|
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
|||||
|
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
|||||
制备储备液
|
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
|
1mM |
1.8568mL |
9.2842mL |
18.5684mL |
|
5mM |
0.3714mL |
1.8568mL |
3.7137mL |
|
10mM |
0.1857mL |
0.9284mL |
1.8568mL |
生物活性
|
产品描述 |
一种有效的 kappa-opioid receptors (KOR) 的拮抗剂，常用于神经系统疾病的研究。 |
|
靶点 |
Opioid Receptor |
|
体内研究 |
JDTic (2.5-16mg/kg,s.c.) dose-dependently blocks the antinociceptive response of nicotine in the tail-flick test but has no effect in the hot-plate assay or body temperature assessments at any dose tested in the mice injected with nicotine.JDTic (3mg/kg,i.p.) is capable of reversing anxiety-like behavior in the rat model of hangover anxiety.JDTic (10mg/kg,i.p.) decreases alcohol self-administration,suppresses cue-induced reinstatement of alcohol seeking,and specifically blocks the effects of a KOR agonist at the 2h pretreatment time point.JDTic (30mg/kg,i.g.) significantly blockes U50,488-induced diuresis immediately in rats. |
推荐实验方法(仅供参考)
|
动物实验: |
|
|
Mice:Naive mice are injected s.c.with JDTic (1,4,8,or 16mg/kg) 18h prior to nicotine (2.5mg/kg,s.c.).Due to JDTic’s very long duration of action,an 18-h preinjection is chosen for the studies.Antinociception using the tail-flick and hot-plate tests is measured 5 min after nicotine injection or 20 min after morphine (8mg/kg,s.c.),and changes in body temperature are measured 30 min after injection.To confirm an absence of mu antagonist effects by JDTic in these studies,JDTic (16mg/kg) is also administered 1,6,18,and 24h before morphine (8 mg/kg,s.c.) in the tail-flick test,and antinociception is measured 20 min after morphine. |
|
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
