中文名称: | Dermorphin | ||||
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英文名称: | Dermorphin | ||||
别名: | 皮啡肽 Tyr-{d-Ala}-Phe-Gly-Tyr-Pro-Ser-NH2 | ||||
CAS No: | 77614-16-5 | 分子式: | C40H50N8O10 | 分子量: | 802.87 |
CAS No: | 77614-16-5 | ||||
分子式: | C40H50N8O10 | ||||
分子量: | 802.87 |
基本信息
产品编号: |
D11506 |
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产品名称: |
Dermorphin |
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CAS: |
77614-16-5 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
802.87 |
-20℃ |
1个月 |
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化学名: |
Tyr-{d-Ala}-Phe-Gly-Tyr-Pro-Ser-NH2 |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
1.2455mL |
6.2277mL |
12.4553mL |
5mM |
0.2491mL |
1.2455mL |
2.4911mL |
10mM |
0.1246mL |
0.6228mL |
1.2455mL |
生物活性
产品描述 |
在两栖类皮肤中发现的一种天然七肽 μ-阿片受体 (MOR) 激动剂。Dermorphin 可用于抑制神经痛。 |
靶点 |
μ-opioid receptor (MOR) |
体外研究 |
Dermorphin,a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ).In displacement binding studies at CHOhMu,Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner.Dermorphin displays an affinity of 7.17,while N/OFQ fails to displace [3H]-DPN at the Delta receptor.Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor. |
推荐实验方法(仅供参考)
激酶实验: |
Membrane protein (40μg) is incubated in 0.5mL volume of 50mM Tris,0.2mM EGTA,1mM MgCl2,100mM NaCl,0.1% BSA,0.15mM bacitracin;pH 7.4,GDP (33μM),and 150pM GTPγ[35S].Varying concentrations of reference ligands (Dermorphin,N/OFQ,Dynorphin-A and Leu-enkephalin) or DeNo (1 pM-10μM) is added prior to incubation.Non-specific binding is determined in the presence of unlabeled GTPγS (10μM).Samples are incubated at 30℃ for 1h with gentle agitation.Reactions are terminated by vacuum filtration through dry Whatman GF/B filters,using a Brandel harvester. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )