中文名称: Ilaprazole 促销
英文名称: Ilaprazole
CAS No: 172152-36-2
分子式: C19H18N4O2S
分子量: 366.44
I10361 Ilaprazole ≥98% (psaitong)
包装规格:
100mg 250mg 1g 5g in glass bottle
溶解性:
溶于DMSO(≥35mg/ml)
产品描述:

基本信息

产品编号:

I10361 

产品名称:

Ilaprazole

CAS:

172152-36-2

 

储存条件

粉末

-20℃

四年

 

 

分子式:

C19H18N4O2S

溶于液体

-80℃

6个月

分子量:

366.44

-20℃

1个月

化学名: 

2-[(4-METHOXY-3-METHYL-PYRIDIN-2-YL)METHYLSULFINYL]-5-PYRROL-1-YL-3H-BENZOIMIDAZOLE

Solubility (25°C):

 

体外:

 

DMSO

73mg/mL (199.21mM)

Ethanol

14mg/mL (38.2mM)

Water

Insoluble

体内(现配现用):

 

1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

2.7290mL

13.6448mL

27.2896mL

5mM

0.5458mL

2.7290mL

5.4579mL

10mM

0.2729mL

1.3645mL

2.7290mL

 

生物活性

产品描述

一种具有口服活性质子泵抑制剂,以剂量依赖性方式不可逆地抑制H+/K+-ATPase,在兔壁细胞制剂中的IC50为6μM。Ilaprazole用于胃溃疡的研究。Ilaprazole也是一种有效的T细胞起源蛋白激酶(TOPK)抑制剂。

靶点

IC50:6.0μM (H+/K+-ATPase)

体外研究

On cumulation of 14C-aminopyrine in histamine stimulated parietal cells,the IC50 of Ilaprazole (IY-81149) sodium is 9nM.

体内研究

Ilaprazole (3-30mg/kg;i.d.) dose-dependently inhibits gastric acid secretion.In anesthetized rats,Ilaprazole dose-dependently increased gastric pH which was lowered by histamine infusion.In the case of i.v.injection,the ED50 of Ilaprazole and omeprazole is 1.2 and 1.4mg/kg and in the case of i.d.administration,the ED50 of Ilaprazole and omeprazole is 3.9 and 4.1mg/kg,respectively.Ilaprazole also significantly inhibits pentagastrin-stimulated gastric secretion.Its ED50 is 2.1mg/kg and that of Omeprazole is 3.5mg/kg with i.d.administration.In the case of i.v.injection,Ilaprazole is equipotent to Omeprazole.Ilaprazole also inhibits gastric acid secretion strongly in fistular rats.The ED50 of Ilaprazole administered intraduodenally is 0.43mg/kg and that of Omeprazole is 0.68mg/kg.

Animal Model:

Male SD rat (after pylorus ligation)

Dosage:

3,10,30mg/kg

Administration:

Intraduodenally

Result:

The acid output and volume significantly inhibited by about 60% and 46% at 3mg/kg were s,respectively.At 30mg/kg,it showed 93% and 73% inhibition on acid output and volume,respectively.

保存条件:
-20℃
UN码:
HazardClass:
危害声明:
安全说明:
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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

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    *
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用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

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  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):