Hesperin - CAS:4430-35-7 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	Hesperin
英文名称:	Hesperin
别名:	6-甲基亚磺酰基异硫氰酸己酯;克林霉素B 2-磷酸酯 6-(methylsulfinyl)hexyl isothiocyanate
CAS No:	4430-35-7	分子式:	C₈H₁₅NOs₂	分子量:	205.34
CAS No:	4430-35-7
分子式:	C₈H₁₅NOs₂
分子量:	205.34

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H10758 Hesperin ≥98% (psaitong)

相关产品

包装规格：

5mg 10mg 50mg 100mg in glass bottle

溶解性：

溶于乙醇(100mg/mL超声）

产品描述：

基本信息

产品编号：	H10758
产品名称：	Hesperin
CAS:	4430-35-7	储存条件	粉末	-20℃	四年
分子式：	C8H15NOs2		溶于液体	-80℃(避光，储于氮)	6个月
分子量：	205.34			-20℃(避光，储于氮)	1个月
化学名：	6-(methylsulfinyl)hexyl isothiocyanate
Solubility (25°C)：
体外:	DMSO
	Ethanol
	Water
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	4.8700mL	24.3499mL	48.6997mL
5mM	0.9740mL	4.8700mL	9.7399mL
10mM	0.4870mL	2.4350mL	4.8700mL

生物活性

产品描述	一种Nrf2活化剂。
靶点	Nrf2
体外研究	Hesperin (6-Methylsulfinylhexyl isothiocyanate,6-MSITC) is an active compound in wasabi (Wasabia japonica Matsum.).Whether Hesperin induces cytotoxicity of HUVECs is determined.More than 1μg/mL of Hesperin markedly induces cytotoxicity and morphological alterations. In subsequent experiments we used Hesperin is used at concentrations of 0-1μg/mL,to study the anti-coagulant and anti-inflammatory properties of Hesperin in HUVECs.
体内研究	Hesperin (6-Methylsulfinylhexyl isothiocyanate,6-MSITC) activates Nrf2 and induces phase II enzyme genes but this induction is absent in Nrf2-null mice,suggesting that Hesperin is a potential activator of the Nrf2/ARE-dependent detoxification pathway.To determine whether Hesperin ameliorates hepatic steatosis and iron accumulation,wild-type and Nrf2-null mice are fed the following diets for 12 weeks:1) control diet,2) high-fat diet (HFD),3) HFD plus Hesperin (10mg/kg/day ip),4) HFD for 6 weeks followed by an iron-supplemented HFD for 6 weeks (HFD/Iron),5) HFD/Iron plus Hesperin.The HFD increased hepatic triglycerides in both genotypes and Hesperin suppress increased hepatic triglycerides in wildtype mice but do not reduce thesetriglycerides in Nrf2-null mice.

推荐实验方法(仅供参考)

细胞实验:

Primary human umbilical vein endothelial cells (HUVECs) are cultured in collagen-coated tissue-culture dishes in an atmosphere containing 95% air and 5% CO2.Human monoblast U937 cells are grown in RPMI-1640 medium with 10% fetal bovine serum,10 U/mL Penicillin,and 10μg/mL Streptomycin.HUVECs are cultured in collagen-coated 96-well plates as confluent monolayers.Hesperin is added into wells at the indicated final concentrations (0-30μg/mL) and then incubated for 24h.Cell viability is measured by cell counting kits.

动物实验:

Mice

A colony of wild-type and Nrf2-null mice are backcrossed with C57BL/6 mice for ten generations.All mice are housed in the same animal care facility controlled for temperature,humidity,and light. Seven-week-old male wild-typeand Nrf2- null mice (n=6-8/group) are divided into five groups fed the following diets:1) a standard diet (AIN-93,containing 4% soybean oil) for 12 weeks and vehicle (1:10 solution of DMSO/PBS) injected intraperitoneally 4 times per week for the last four weeks (control group),2) a high-fat diet (HFD) (containing 4% soybean oil and 31% lard) for 12 weeks and vehicle injected intraperitoneally 4 times per week for the last four weeks (HFD group),3) a HFD for 12 weeks and Hesperin (10mg/Kg/day;dissolved in 1:10 solution of DMSO/PBS) injected intraperitoneally 4 times per week for the last four weeks (HFD+ Hesperin),4) a HFD for 6 weeks followed by a HFD containing 1% carbonyl iron for 6 weeks and vehicle injected intraperitoneally 4 times per week for the last four weeks(HFD+Iron),and 5) a HFD for 6 weeks followed by a HFD containing 1% carbonyl iron for 6 weeks and Hesperin (10mg/Kg/day) injected intraperitoneally 4 times per week for the last four weeks (HFD+Iron+Hesperin).After 12 weeks,blood samples are collected by cardiac puncture under anesthesia with sodium pentobarbital (50mg/kg,ip) and livers are harvested and stored at -80℃ until analysis.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果