| 中文名称: | 醋酸氟卡尼 | ||||
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| 英文名称: | Flecainide acetate | ||||
| 别名: | 醋酸氟卡尼 R-818 | ||||
| CAS No: | 54143-56-5 | 分子式: | C17H20F6N2O3.C2H4O2 | 分子量: | 474.39 |
| CAS No: | 54143-56-5 | ||||
| 分子式: | C17H20F6N2O3.C2H4O2 | ||||
| 分子量: | 474.39 | ||||
基本信息
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产品编号： |
F10450 |
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产品名称： |
Flecainide acetate |
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CAS: |
54143-56-5 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
474.39 |
-20℃ |
1个月 |
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化学名： |
Benzamide,N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-,monoacetate |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.1080mL |
10.5399mL |
21.0797mL |
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5mM |
0.4216mL |
2.1080mL |
4.2159mL |
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10mM |
0.2108mL |
1.0540mL |
2.1080mL |
生物活性
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产品描述 |
能阻断位于心脏的Nav1.5钠离子通道，能抗心律失常。 |
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靶点 |
Nav1.5 |
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体外研究 |
Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia.Flecainide works by blocking the Nav1.5 sodium channel in the heart,causing prolongation of the cardiac action potential.in vitro:Under the current-clamp condition,flecainide (1-100 microM) prolonged the action potential duration at both the early and the late phases of repolarization in a concentration-dependent manner without affecting the resting membrane potential.At a holding potential (HP) of -120 mV,flecainide use-dependently blocked WT and G1306E I(Na) equally but was more potent on R1448C channels.For WT,the extent of block depended on a holding voltage more negative than the activation threshold,being greater at -90 mV as compared to-120 and -180 mV.in vivo:Flecainide (80-130mg/m(2) orally) resulted in termination of the tachycardia in all 8 patients.Acute pharmacological termination of arrhythmia occurred with oral flecainide loading in 1 and temporarily with intravenous esmolol loading in 1 patient.Adjuvant therapy in form of propranolol was used in 5 and digoxin in 2. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
