| 中文名称: | 盐酸去甲咪嗪 | ||||
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| 英文名称: | Desipramine hydrochloride | ||||
| 别名: | 盐酸地昔帕明 Desmethylimipramine monohydrochloride | ||||
| CAS No: | 58-28-6 | 分子式: | C18H23ClN2 | 分子量: | 302.84 |
| CAS No: | 58-28-6 | ||||
| 分子式: | C18H23ClN2 | ||||
| 分子量: | 302.84 | ||||
基本信息
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产品编号： |
D70300 |
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产品名称： |
Desipramine hydrochloride |
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CAS: |
58-28-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
两年 |
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分子量 |
302.84 |
-20℃ |
1个月 |
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化学名： |
10,11-Dihydro-5-(3-(methylamino)propyl)-5H-dibenz(b,f)azepine hydrochloride |
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Solubility (25°C)： |
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体外:
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DMSO |
60 mg/mL (198.12mM) |
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Water |
60 mg/mL (198.12mM) |
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Ethanol |
60 mg/mL (198.12mM) |
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体内(现配现用): |
1.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: ≥ 2.5 mg/mL (8.26mM); Clear solution |
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此方案可获得 ≥ 2.5 mg/mL (8.26mM，饱和度未知) 的澄清溶液。以 1mL 工作液为例，取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中，混合均匀；向上述体系中加入50μL Tween-80，混合均匀；然后继续加入 450μL生理盐水定容至 1mL。 |
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2.请依序添加每种溶剂：10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (8.26mM); Clear solution |
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此方案可获得 ≥ 2.5 mg/mL (8.26mM，饱和度未知) 的澄清溶液。以 1mL 工作液为例，取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。 |
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3.请依序添加每种溶剂：10% DMSO→90% corn oil Solubility: ≥ 2.5 mg/mL (8.26mM); Clear solution |
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此方案可获得 ≥ 2.5 mg/mL (8.26mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。以 1mL 工作液为例，取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900μL玉米油中，混合均匀。 |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.3021mL |
16.5104mL |
33.0207mL |
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5mM |
0.6604mL |
3.3021mL |
6.6041mL |
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10mM |
0.3302mL |
1.6510mL |
3.3021mL |
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50mM |
0.0660mL |
0.3302mL |
0.6604mL |
生物活性
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产品描述 |
一种去甲肾上腺素转运蛋白 (NET), 5-羟色胺转运体 (SERT) 和多巴胺转运 (DAT) 的抑制剂。 |
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靶点 |
Ki: 4nM (NET), 61nM (SERT), 78720nM (DAT) |
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体内研究 |
Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of 3H-nisoxetine to the NET in preparations of cerebral cortex (F(3,16)=4.33, p<0.05) and hippocampus (F(3,16)=4.34, p<0.05). This NET down regulation is observed 2 days after discontinuation of chronic Desipramine hydrochloride treatment, a time when plasma and brain concentrations of Desipramine hydrochloride and desmethyldesipramine are undetectable (ie below the 25 ng detection limit of the assay). |
推荐实验方法(仅供参考)
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Animal Administration |
Rats are anesthetized with ketamine (100 mg/kg) and xylazine (10 mg/kg) and implanted subcutaneously with osmotic minipumps preloaded with either vehicle (50% saline, 40% DMSO, and 10% ethanol) or Desipramine hydrochloride at a concentration that delivered 5, 10, or 15 mg/kg per day of the free base. Minipumps are removed, under anesthesia, 14 days later. Rats are tested for antidepressant-like behavior in the forced-swim test 2 to 8 days after pump removal and discontinuation of Desipramine hydrochloride treatment. Following the completion of the behavioral tests, rats are killed by decapitation, their brains are removed, and cerebral cortex and hippocampus are dissected for neurochemical analyses. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
