| 中文名称: | CP-471474 | ||||
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| 英文名称: | CP-471474 | ||||
| 别名: | CP-471474 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydrox y-2-methylpropanamide | ||||
| CAS No: | 210755-45-6 | 分子式: | C16H17FN2O5S | 分子量: | 368.38 |
| CAS No: | 210755-45-6 | ||||
| 分子式: | C16H17FN2O5S | ||||
| 分子量: | 368.38 | ||||
基本信息
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产品编号： |
C70139 |
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产品名称： |
CP-471474 |
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CAS: |
210755-45-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
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分子量 |
368.38 |
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化学名： |
2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydrox y-2-methylpropanamide |
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生物活性
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产品描述 |
一个口服有效的、广泛的MMP抑制剂。 |
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靶点 |
MMP-2 0.7nM(IC50) |
MMP-13 0.9nM(IC50) |
MMP-9 13nM(IC50) |
MMP-3 16nM(IC50) |
MMP-1 1170nM(IC50) |
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体外研究 |
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体内研究 |
CP-471474 plasma levels following subcutaneous injection are 2,020ng/mL (1 h postdose) to 160ng/mL (6 h postdose). CP-471,474 significantly reduces both the extent and severity of inflammation at 2 months. At 4 months, a spontaneous reduction of the inflammatory response is observed in both treated and untreated animals, and consequently no difference is observed between both. CP-471474 significantly decreases the destructive lesions mainly at 2 months and also at 4 months |
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Animal Model: |
Guinea pigs weighing 400 to 450 g (COPD) |
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Dosage: |
20 mg/kg (also supplemented daily by the diet (200 mg/200 g powdered chow)). |
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Administration: |
Subcutaneously (in 20% ethanol/80% polyethylene glycol), once a day during the entire course. |
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Result: |
Lungs derived from smoking animals treated with the compound demonstrated a statistically significant reduction in the destructive lesions. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
