| 中文名称: | Bradykinin (1-5) | ||||
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| 英文名称: | Bradykinin (1-5) | ||||
| 别名: | 1-5-血管舒缓激肽 Arg-Pro-Pro-Gly-Phe | ||||
| CAS No: | 23815-89-6 | 分子式: | C27H4N8O6 | 分子量: | 572.66 |
| CAS No: | 23815-89-6 | ||||
| 分子式: | C27H4N8O6 | ||||
| 分子量: | 572.66 | ||||
| MDL: | MFCD00076260 | ||||
![[Des-Arg9]-缓激肽](http://struc.chem960.com/strucimg/16000/le1hdxlxgxjlsxqt3o6cbqee.png)
基本信息
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产品编号：B10856 |
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产品名称：Bradykinin (1-5) |
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CAS: |
23815-89-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量： |
572.66 |
-20℃ |
一个月 |
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化学名： |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内（现配现用） |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
1.7462mL |
8.7312mL |
17.4624mL |
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5mM |
0.3492mL |
1.7462mL |
3.4925mL |
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10mM |
0.1746mL |
0.8731mL |
1.7462mL |
生物活性
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产品描述 |
是 Bradykinin 的主要稳定代谢物，由血管紧张素转换酶 (ACE) 经蛋白水解作用形成。 |
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靶点/IC50 |
Bradykinin Receptor |
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体外研究 |
Bradykinin is a short-lived vasoactive peptide, with a reported half-life in vivo of 17 s,that is rapidly metabolized in the circulation to Bradykinin (1-5). Bradykinin (1-5),the product of two sequential cleavages of Bradykinin by ACE at the Pro7-Phe8 and Phe5-Ser6bonds, has been identified as the major stable metabolite of Bradykinin in vivo in human subjects, with a terminal half-life of minutes. Both Bradykinin and Bradykinin (1-5) inhibit α- and γ-thrombin-induced platelet aggregation (P<0.01 versus baseline). Bradykinin (1-5) inhibits γ-thrombin-induced platelet aggregation 50% at a calculated dose of 183±3 pmol/min. Neither Bradykinin nor Bradykinin (1-5) affects thrombin receptor-activating peptide-induced platelet aggregation,consistent with the hypothesis that Bradykinin and Bradykinin 1-5 inhibit thrombin-induced platelet aggregation by preventing cleavage of the thrombin receptor and liberation of thrombin receptor-activating peptide.Bradykinin (1-5) significantly attenuates α-thrombin-induced platelet aggregation but not TRAP 1-6-induced platelet aggregation. Bradykinin (1-5) potently inhibits γ-thrombin (500nM)-induced platelet aggregation with an ED50 of 183±2 pmol/min. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
