| 中文名称: | 磷酸苯丙哌啉 促销 | ||||
|---|---|---|---|---|---|
| 英文名称: | Benproperine phosphate | ||||
| 别名: | 科福乐 Benproperine phosphate | ||||
| CAS No: | 19428-14-9 | 分子式: | C21H30NO5P | 分子量: | 407.44 |
| CAS No: | 19428-14-9 | ||||
| 分子式: | C21H30NO5P | ||||
| 分子量: | 407.44 | ||||
| EINEC: | 243-050-0 | ||||
| EINEC: | 243-050-0 | ||||
基本信息
|
产品编号：B10786 |
|||||
|
产品名称：Benproperine phosphate |
|||||
|
CAS: |
19428-14-9 |
储存条件 |
粉末 |
2-8℃ |
四年 |
|
|
|
||||
|
分子式： |
溶于液体 |
-80℃ |
六个月 |
||
|
分子量 |
407.44 |
-20℃ |
一个月 |
||
|
化学名： |
|
||||
|
Solubility (25°C) |
体外 |
DMSO |
81mg/mL (198.8mM) |
||
|
Ethanol |
60mg/mL (147.26mM) |
||||
|
Water |
3mg/mL (7.36mM) |
||||
|
体内（现配现用） |
|
|
|||
|
＜1mg/ml表示微溶或不溶。 |
|||||
|
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
|||||
|
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
|||||
制备储备液
|
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
|
1mM |
2.4543mL |
12.2717mL |
24.5435mL |
|
5mM |
0.4909mL |
2.4543mL |
4.9087mL |
|
10mM |
0.2454mL |
1.2272mL |
2.4543mL |
|
50mM |
0.0491mL |
0.2454mL |
0.4909mL |
生物活性
|
产品描述 |
一种具有口服活性的，有效的肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。Benproperine phosphate 通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。 |
|
|
靶点/IC50 |
Arp2/3 Complex |
|
|
体外研究 |
Benproperine phosphate (20-120μM; for 24 hours) inhibits cell viability in a dose-dependent manner.Benproperine phosphate (10μM;for 24 hours) significantly inhibits the migration of various types of cancer cells and inhibits the migration and invasion of DLD-1,AsPC-1 cells with IC50 values of 1-2μM. Benproperine phosphate (10μM; for 24 hours) does not affect cortactin-rich lamellipodium in MCF-10A cells. Cell Viability Assay |
|
|
Cell Line: |
DLD-1, AsPC-1, CFPAC-1, A375P, A375P, MDA-MB-231, DU145, DU145 cancer cells |
|
|
Concentration: |
20, 40, 60, 80, 100, 120μM |
|
|
Incubation Time: |
For 24 hours |
|
|
Result: |
Inhibited cell viability in a dose-dependent manner. |
|
|
体内研究 |
Benproperine phosphate (50, 100mg/kg; oral gavage;5 days per week for 4 weeks) inhibits primary pancreatic tumor growth.Benproperine phosphate shows a marked decrease in the lung metastasis of AsPC-1 cells (56.1% inhibition) in mouse.Benproperine phosphate significantly suppressed the liver metastasis of HCT-116 cells by 78.9% and DLD-1 cells by 78.2%. |
|
|
Animal Model: |
Female BALB/c nude mice of 6-week-old with AsPC-1 cells |
|
|
Dosage: |
50, 100mg/kg |
|
|
Administration: |
Oral gavage; 5 days per week for 4 weeks |
|
|
Result: |
Inhibited primary pancreatic tumor growth compared to the vehicle control (47.7% inhibition) without body weights change. |
|
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
