| 中文名称: | ZD-4190 | ||||
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| 英文名称: | ZD-4190 | ||||
| 别名: | ZD-4190 ZD-4190 | ||||
| CAS No: | 413599-62-9 | 分子式: | C19H16BrFN6O2 | 分子量: | 459.27 |
| CAS No: | 413599-62-9 | ||||
| 分子式: | C19H16BrFN6O2 | ||||
| 分子量: | 459.27 | ||||
基本信息
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产品编号：Z10067 |
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产品名称：ZD-4190 |
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CAS: |
413599-62-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
两年 |
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分子量 |
459.27 |
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化学名： |
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Solubility (25°C) |
体外 |
DMSO |
12mg/mL (26.12mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内（现配现用） |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.1774mL |
10.8868mL |
21.7737mL |
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5mM |
0.4355mL |
2.1774mL |
4.3547mL |
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10mM |
0.2177mL |
1.0887mL |
2.1774mL |
生物活性
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产品描述 |
一种有效的，可口服的VEGFR2和EGFR的抑制剂，用于癌症研究。 |
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靶点/IC50 |
EGFR |
VEGFR2 |
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体外研究 |
ZD4190 exhibits cytotoxic activity against the tumor cells. |
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体内研究 |
ZD4190 (100mg/kg, p.o.) effectively delays MDA-MB-435 tumor growth in mice. In ZD4190-treated tumors, 18F-FPPRGD2 uptake has decreased significantly relative to baseline by 26.74±8.12% (p<0.05) on day 1 and by 41.19±6.63% (p<0.01) on day 3, then has returned to baseline on day 7. Tumor uptake of 18F-FLT has also decreased on both day 1 and day 3 after initiation of ZD4190 treatment. However, ZD4190 does not significantly change 18F-FDG uptake in tumors, compared with the control group. ZD4190 (50mg/kg, p.o.) prevents outgrowth of residual tumour in a muscle model of minimal residual carcinoma. ZD4190 (12.5-100mg/kg, p.o.) produces a dose-dependent reduction in K(trans) in PC-3 prostate tumors. At 100 mg/kg, ZD4190 reduces K(trans) in PC-3 tumors by 31% following 2 doses and by 53% following 8 doses. |
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推荐实验方法(仅供参考)
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细胞实验: |
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The cytotoxicity of ZD4190 for PDVC57B cells is established when 104 cells are exposed to 1-10μM ZD4190 for 96 h before MTS solution is added and the optical density measured at 490nm. Cells are also grown to 40% confluence and treated with 1-100μM ZD4190 for 7 days and the cytopathic effect examined by staining with crystal violet |
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动物实验: |
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ZD4190 is suspended in a 1% (v/v) solution of polyoxyethylene sorbitan mono-oleate in deionized water and administered by oral gavage (0.1mL/10 g body weight). In each experiment, mice are randomized to receive either vehicle or ZD4190, administered once daily using a 1 day (at 0 and 22h) or 7 day (at 0, 24, 48, 72, 96, 120, 144, and 166h) treatment regimen (i.e., daily administration of compound for 1 or 7 days with an additional dose given 2h prior to the end of the treatment period) followed by DCEMRI under terminal anesthesia. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
