中文名称: 唑来磷酸一水化合物 促销
英文名称: Zoledronic acid monohydrate
CAS No: 165800-06-6
分子式: C5H10N2O7P2.H2O
分子量: 290.1
Z10002 唑来磷酸一水化合物 ≥98% (HPLC) (psaitong)
包装规格:
1g 5g in glass bottle
溶解性:
溶于水( ≥2mg/mL )
产品描述:

基本信息

产品编号:Z10002

产品名称:Zoledronic acid monohydrate

CAS:

165800-06-6

 

储存条件

粉末

2-8℃

四年

 

 

分子式:

C5H10N2O7P2.H2O

溶于液体

-80℃

两年

分子量

290.10

-20℃

一个月

化学名: 

(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid hydrate

 

Solubility (25°C)

 

体外

DMSO

0.01mg/mL (0.03mM)

Ethanol

Insoluble

Water

Insoluble

体内

现配现用

 

1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

3.4471mL

17.2354mL

34.4709mL

5mM

0.6894mL

3.4471mL

6.8942mL

10mM

0.3447mL

1.7235mL

3.4471mL

 

生物活性

产品描述

一种高活性的双膦酸盐和PKC激活剂。

靶点/IC50

Ras 
()

Rho 
()

 

体外研究

Zoledronic Acid monohydrate (0.1-1 µM; 48 hours) increases receptor activator of nuclear factor kB ligand (RANKL) and sclerostin mRNA expressions in osteocyte-like MLO-Y4 cells.

Zoledronic Acid monohydrate increases the expression of osteoclastogenesis supporting factor from MLO-Y4 cells.

Zoledronic Acid monohydrate enhances the RANKL expression via IL-6/ JAK2/STAT3 pathway in MLO-Y4 cells.

Zoledronic Acid monohydrate inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways.

Zoledronic Acid monohydrate (10-100µM; 1-7 days) markedly reduces the viability of MC3T3-E1 cells.

Zoledronic Acid monohydrate (10-100µM; 1-7 days) induces apoptosis in MC3T3-E1 cells.

Zoledronic Acid monohydrate (10-100µM; 4 days) inhibits cell viability due to the induction of apoptosis.

Zoledronic Acid monohydrate exerts inhibitory effects on the differentiation and maturation of MC3T3-E1 cells at concentrations <1µM.

Cell Viability Assay

Cell Line:

MC3T3-E1 cells

Concentration:

0.02µM , 0.1µM, 1µM, 10µM, 100µM

Incubation Time:

1day, 3days, 5days, 7days

Result:

Reduced cells viability at 10µM and 100µM.

Apoptosis Analysis

Cell Line:

MC3T3-E1 cells

Concentration:

0.02µM , 0.1µM, 1µM, 10µM, 100µM

Incubation Time:

1days, 4days, 7days

Result:

Increased the number of early apoptotic cells and late apoptotic or necrotic cells at dosedependent and time-dependent (high concentrations).

Western Blot Analysis

Cell Line:

MC3T3-E1 cells

Concentration:

0.02µM , 0.1µM, 1µM, 10µM, 100µM

Incubation Time:

4days

Result:

Down-regulated the protein level of inactive caspase-3 and up-regulated the protein level of active caspase-3 at the concentrations of 10 and 100µM.

 

体内研究

Zoledronic Acid monohydrate (0.05mg/kg; i.p.; weekly; for 3weeks) increases bone mineral density and content.

Zoledronic Acid monohydrate (0.5-1mg/kg; i.p.; weekly; for 3weeks) inhibits both osteoclast and osteoblasts function and bone remodeling in vivo interfering with bone mechanical properties.

Animal Model:

Five-week-old C57BL6 mice

Dosage:

0.05mg/kg, 0.5mg/kg, 1mg/kg

Administration:

Intraperitoneal injection, weekly, for 3weeks

Result:

Intraperitoneal injection, weekly, for 3weeks.

保存条件:
2-8℃
UN码:
HazardClass:
危害声明:
安全说明:
搜索质检报告(COA)
参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • =
    *
    *
    *选择对应的单位 *空出希望得到的变量,填写另外两个变量

用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):