中文名称: | WAY-100635 | ||||
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英文名称: | CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) | ||||
别名: | N-[2-[4-(2-甲氧基苯基)-1-哌嗪基]乙基]-N-2-吡啶基-环己烷羧胺 Way 100635;N-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide | ||||
CAS No: | 162760-96-5 | 分子式: | C25H34N4O2 | 分子量: | 422.56 |
CAS No: | 162760-96-5 | ||||
分子式: | C25H34N4O2 | ||||
分子量: | 422.56 |
基本信息
产品编号: |
W10042 |
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产品名称: |
WAY-100635 |
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CAS: |
162760-96-5 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
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分子量 |
422.56 |
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化学名: |
cyclohexanecarboxamide, n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinyl- |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
一种有效且具有选择性的 5-hydroxytryptamine 1A (5-HT1A) 受体拮抗剂,其 IC50 值为 0.91nM,Ki 值为 0.39nM。 |
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靶点 |
5-HT1A Receptor 8.87 (pIC50) |
5-HT1A Receptor 9.71 (pA2) |
体外研究 |
The functional properties and binding affinities of WAY-100635 are evaluated in HEK 293 cells stably expressing dopamine D 2L or D4.4 receptors. WAY-100635 displays 940, 370, and 16 nM binding affinities at D2L, D3, and D4.2 receptors, respectively. Saturation analyses demonstrat that the Kd of [3H] WAY-100635 at D4.2 receptors is 2.4nM. WAY-100635 is potent agonist in HEK-D4.4 cells with EC 50 of 9.7nM. WAY-100635 possesses high affinity for D4.4 receptor (3.3nM) . |
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体内研究 |
WAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) treatment abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat. |
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Animal Model: |
Male Sprague-Dawley rats (220-240 g) |
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Dosage: |
1 mg/kg |
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Administration: |
Subcutaneous injection (Pharmacokinetic study) |
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Result: |
Reduced total abstinence score, increased immobility time and the burying behavior was increased. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )