中文名称: | 盐酸维那卡兰 | ||||
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英文名称: | Vernakalant Hydrochloride | ||||
别名: | 盐酸维那卡兰 RSD1235hydrochloride | ||||
CAS No: | 748810-28-8 | 分子式: | C20H32ClNO4 | 分子量: | 385.93 |
CAS No: | 748810-28-8 | ||||
分子式: | C20H32ClNO4 | ||||
分子量: | 385.93 |
基本信息
产品编号: |
V10155 |
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产品名称: |
Vernakalant Hydrochloride |
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CAS: |
748810-28-8 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
385.93 |
-20℃ |
1个月 |
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化学名: |
(3R)-1-((1R,2R)-2-(2-(3,4-dimethoxyphenyl)ethoxy)cyclohexyl)pyrrolidin-3-ol hydrochloride |
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Solubility (25°C): |
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体外:
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DMSO |
77mg/mL (199.51mM) |
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Ethanol |
77mg/mL (199.51mM) |
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Water |
77mg/mL (199.51mM) |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.5911mL |
12.9557mL |
25.9114mL |
5mM |
0.5182mL |
2.5911mL |
5.1823mL |
10mM |
0.2591mL |
1.2956mL |
2.5911mL |
生物活性
产品描述 |
一种混合电压和频率依赖性的Na+和K+通道阻断剂。 |
靶点 |
IC50:13.35±0.93μM (Kv1.5 channelwt),0.61±0.03μM (I508F),1.63±0.09μM (Kv1.5 channel T479A) |
体外研究 |
Block of Kv1.5 by Vernakalant Hydrochloride is mediated after channel activation,because Vernakalant causes a relatively rapid onset of block of channel current upon depolarization but little evidence of resting or“tonic”block of the channel.In the presence of 10μM Vernakalant,rapid block is apparent after channel opening,and a steady-state current level is rapidly reached.The most important effect is the reduction in potency for Vernakalant centered at I502A,which had an IC50 of 329±19μM (n=4-10),compared with a control IC50 of 13.4±0.9μM (n=5-23),which is a 25-fold decrease in potency.V505A,I508A,T480A,and C500A showed lesser reductions in potency on Kv1.5,of between 3-and 4-fold.I508Y in our experiments increased the IC50 for Vernakalant on Kv1.5 to 24.7μM,again similar to the reported value for hERG. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )