| 中文名称: | 维拉必利 | ||||
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| 英文名称: | Veralipride | ||||
| 别名: | 吡藜酰胺;N-[(1-烯丙基吡咯烷-2-基)甲基]-2,3-二甲氧基-5-氨基磺酰基苯甲酰胺 (±)-Veralipride; LIR166 | ||||
| CAS No: | 66644-81-3 | 分子式: | C17H25N3O5S | 分子量: | 383.46 |
| CAS No: | 66644-81-3 | ||||
| 分子式: | C17H25N3O5S | ||||
| 分子量: | 383.46 | ||||
| MDL: | MFCD00867658 | EINEC: | 266-435-5 | ||
| EINEC: | 266-435-5 | ||||
基本信息
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产品编号：V10109 |
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产品名称：Veralipride |
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CAS: |
66644-81-3 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量： |
383.46 |
-20℃ |
一个月 |
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化学名： |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内（现配现用） |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.6078mL |
13.0392mL |
26.0783mL |
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5mM |
0.5216mL |
2.6078mL |
5.2157mL |
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10mM |
0.2608mL |
1.3039mL |
2.6078mL |
生物活性
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产品描述 |
是 D2 受体的拮抗剂。 它是一种替代抗抑郁药研究绝经期症状的化合物。 |
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靶点/IC50 |
Dopamine Receptor |
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体外研究 |
Veralipride administration (100mg/day for 30 days) induces a significant reduction in vasomotor symptoms and is more effective than placebo.Treatment is followed by the expected increase in plasma prolactin levels and by a significant decrease in mean plasma LH.A significant reduction is observed in objectively recorded hot flushes after Veralipride treatment.Veralipride is well absorbed when administered orally,achieving maximal concentrations at 2.5 hours.It is poorly metabolized and is eliminated in the urine and feces.After oral administration,the half-life is 4 hours,and 44% is excreted without any changes in urine in the first 120 hours.A total of 57 adverse events are registered during the 386-month treatment.For the 20×10 dosing schedule,the highest incidence is observed for anxiety (2.2%), drowsiness,and weakness (1.5%);for the 5×2 dosing schedule,the highest incidence is observed for drowsiness (5.3%) and headache (2.6%).Veralipride is known to cause extrapiramidal signs such as bucco-facial or limb dyskinesia.Veralipride may cause reversible parkinsonism. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
