中文名称: | Ubiquitin Isopeptidase Inhibitor I, G5 | ||||
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英文名称: | Ubiquitin Isopeptidase Inhibitor I, G5 | ||||
别名: | NSC144303 | ||||
CAS No: | 108477-18-5 | 分子式: | C19H14N2O7S | 分子量: | 414.39 |
CAS No: | 108477-18-5 | ||||
分子式: | C19H14N2O7S | ||||
分子量: | 414.39 |
基本信息
产品编号:U10059 |
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产品名称:Ubiquitin Isopeptidase Inhibitor I, G5 |
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CAS: |
108477-18-5 |
储存条件 |
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-20℃ |
四年 |
4℃ |
两年 |
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分子式: |
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分子量 |
414.39 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内(现配现用) |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.4132mL |
12.0659mL |
24.1319mL |
5mM |
0.4826mL |
2.4132mL |
4.8264mL |
10mM |
0.2413mL |
1.2066mL |
2.4132mL |
生物活性
产品描述 |
一种凋亡不依赖的半胱天冬酶和细胞凋亡的激活剂,对E1A和E1A/C9DN细胞的IC50值分别为1.76和1.6μM。 |
靶点/IC50 |
IC50: 1.76μM (E1A cells),1.6μM (E1A/C9DN cells) |
体外研究 |
G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway.G5 is a potent apoptotic inducer showing IC50s of 1.76 and 1.6μM in E1A and E1A/C9DN cells, respectively. |
推荐实验方法(仅供参考)
细胞实验: |
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Different drug concentrations are used to determine the dose-response profile and to calculate the IC50 value. Cells are incubated with the required concentrations of the 57 compounds. After 24 or 48 hours of incubation, cell death is evaluated bytr ypan blue staining. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )