| 中文名称: | 硫利达嗪 | ||||
|---|---|---|---|---|---|
| 英文名称: | Thioridazine | ||||
| 别名: | Mellaril;Sonapax | ||||
| CAS No: | 50-52-2 | 分子式: | C21H26N2S2 | 分子量: | 370.57 |
| CAS No: | 50-52-2 | ||||
| 分子式: | C21H26N2S2 | ||||
| 分子量: | 370.57 | ||||
包装规格：
5mg 50mg 100mg in glass bottle
产品简介：
Thioridazine 是一种具有口服活性的多巴胺受体 D2 家族蛋白的拮抗剂，具有有效的抗焦虑活性。Thioridazine 也是一种有效的 PI3K-Akt-mTOR 信号通路的抑制剂，具有抗血管生成作用。Thioridazine 在多种类型的癌细胞中显示出抗增殖和凋亡诱导作用，对靶向癌症干细胞 (CSCs) 具有特异性。
体外研究：
Thioridazine (0.01-100 μM; 48 h) reduces the cell viability of NCI-N87 and AGS cells in a concentration-dependent manner.
Thioridazine (15 μM; 24 h) reduces cell viability of the cervical (HeLa, Caski and C33A) and endometrial (HEC-1-A and KLE) cancer cells.
Thioridazine (1-15 μM; 24-48 h) induces gastric cancer cell death via the mitochondrial apoptosis pathway and mitochondrial pathway.
Thioridazine (15 μM; 24 h) modulates the regulation of cell cycle progression by interfering with the PI3K/Akt pathway and induces G1 cell cycle arrest in cervical and endometrial cancer cells.
Thioridazine inhibits the growth of antibiotic-sensitive and multidrug-resistant strains of A. baumannii
Thioridazine (15 μM; 24 h) reduces cell viability of the cervical (HeLa, Caski and C33A) and endometrial (HEC-1-A and KLE) cancer cells.
Thioridazine (1-15 μM; 24-48 h) induces gastric cancer cell death via the mitochondrial apoptosis pathway and mitochondrial pathway.
Thioridazine (15 μM; 24 h) modulates the regulation of cell cycle progression by interfering with the PI3K/Akt pathway and induces G1 cell cycle arrest in cervical and endometrial cancer cells.
Thioridazine inhibits the growth of antibiotic-sensitive and multidrug-resistant strains of A. baumannii
体内研究：
Thioridazine (25 mg/kg; i.p. every 3 days for 3 weeks) extends the survival of tumor-bearing mice and reduces the number of pluripotent embryonal carcinoma (EC) cells within tumors.
Thioridazine (1.0-5.0 mg/kg; s.c.) reduces oral behavior and selectively blocks repetitive head bobbing.
Thioridazine (1.0-5.0 mg/kg; s.c.) reduces oral behavior and selectively blocks repetitive head bobbing.
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
保存条件：
室温 密封干燥
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质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
