| 中文名称: | (±)-他齐茶碱 | ||||
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| 英文名称: | (±)-Tazifylline | ||||
| 别名: | 他齐茶碱 7-[2-hydroxy-3-[4-(3-phenylsulfanylpropyl)piperazin-1-yl]propyl]-1,3-dimethylpurine-2,6-dione | ||||
| CAS No: | 79712-55-3 | 分子式: | C23H32N6O3S | 分子量: | 472.6 |
| CAS No: | 79712-55-3 | ||||
| 分子式: | C23H32N6O3S | ||||
| 分子量: | 472.6 | ||||
基本信息
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产品编号： |
T11451 |
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产品名称： |
(±)-Tazifylline |
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CAS: |
79712-55-3 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
二年 |
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分子量 |
472.60 |
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化学名： |
7-[2-hydroxy-3-[4-(3-phenylsulfanylpropyl)piperazin-1-yl]propyl]-1,3-dimethylpurine-2,6-dione |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种有效的，选择性的长效组胺 H1 受体拮抗剂。 |
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靶点 |
H1-receptor |
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体外研究 |
Tazifylline potently inhibits contractions evoked by stimulation of histamine H1-receptors in isolated guinea pig ilea and exhibits high affinity for these receptors in radioligand binding studies in vitro Tazifylline has much lower affinity for histamine H2-receptors,alpha- and beta-adrenoceptors,5-hydroxytryptamine and muscarinic receptor subtypes.Tazifylline poorly inhibits the release of histamine from rat peritoneal mast cells. |
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体内研究 |
In rats,guinea pigs and dogs the antihistaminic effect of Tazifylline is rapid in onset and long-lived.In anesthetized guinea pigs,Tazifylline markedly inhibits histamine-induced bronchoconstriction and protects conscious animals from the lethal effect of large doses of the amine.In conscious rats,Tazifylline is more potent in reducing the inflammatory effects of intradermal histamine than that evoked by anaphylactic reaction.In conscious dogs,orally administered Tazifylline inhibits histamine-induced skin inflammation for long periods of time and in anesthetized animals attenuated that portion of the histamine-evoked hypotension attributable to stimulation of H1-receptors.Large oral doses of Tazifylline does not reduce spontaneous locomotor activity in mice,nor do they produce overt symptoms of behavioral depression in conscious rats. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
