中文名称: | Tacrine hydrochloride | ||||
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英文名称: | Tacrine hydrochloride | ||||
别名: | 盐酸他克林;1,2,3,4-四氢吖啶-9-胺盐酸盐 1,2,3,4-Tetrahydroacridin-9-amine hydrochloride | ||||
CAS No: | 1684-40-8 | 分子式: | C13H15ClN2 | 分子量: | 234.72 |
CAS No: | 1684-40-8 | ||||
分子式: | C13H15ClN2 | ||||
分子量: | 234.72 | ||||
EINEC: | 216-867-5 | ||||
EINEC: | 216-867-5 |
基本信息
产品编号: |
T11016 |
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产品名称: |
Tacrine hydrochloride |
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CAS: |
1684-40-8 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
两年 |
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分子量 |
234.72 |
-20℃ |
1个月 |
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化学名: |
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Solubility (25°C): |
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体外:
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DMSO |
46 mg/mL (195.97mM) |
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Water |
46 mg/mL (195.97mM) |
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Ethanol |
46 mg/mL (195.97mM) |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
4.2604mL |
21.3020mL |
42.6040mL |
5mM |
0.8521mL |
4.2604mL |
8.5208mL |
10mM |
0.4260mL |
2.1302mL |
4.2604mL |
50mM |
0.0852mL |
0.4260mL |
0.8521mL |
生物活性
产品描述 |
一种AChE和BChE的有效抑制剂,可用于研究阿尔茨海默氏症 |
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靶点 |
BChE |
AChE |
25.6nM |
31nM |
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体外研究 |
Tacrine (12.5-37.5nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner. Tacrine reduces the neurotoxicity induced by the activation of the NMDARs in murine cortical neuronal cultures with an IC50 of ~500μM. Tacrine inhibits the NMDAR responses in a concentration-dependent manner with an IC50 of ~190μM at -60mV. |
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体内研究 |
Tacrine (20-40μmol/kg; s.c.) disrupts retention of learning in 17- and 30-day old mice in passive avoidance, and while the low dose of tacrine treatment (5 μmol/kg; s.c.) improves retention in 17-day old mice.Tacrine (0.1-0.4 mg/mL; i.p. for 7 d) inhibits the expression of AChE, but does not significantly improve the protection of the retina function and morphology in mice. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )