土曲霉酮 - CAS:582-46-7 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	土曲霉酮
英文名称:	Terrein
别名:	土曲霉酮 Terrein
CAS No:	582-46-7	分子式:	C₈H₁₀O₃	分子量:	154.16
CAS No:	582-46-7
分子式:	C₈H₁₀O₃
分子量:	154.16

安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF)

T10737 土曲霉酮 ≥98% (psaitong)

相关产品

包装规格：

2.5mg 10mg in glass bottle

产品描述：

基本信息

产品编号：T10737
产品名称：Terrein
CAS:	582-46-7	储存条件	粉末	-20℃	四年
分子式：	C8H10O3		溶于液体	-80℃	两年
分子量	154.16
化学名：
Solubility (25°C)	体外	DMSO
		Ethanol
		Water
	体内（现配现用）
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

生物活性

产品描述	一种黑色素生成抑制剂。Terrein 诱导乳腺癌细胞凋亡 (apoptosis)。Terrein是铜绿假单胞菌 (Pseudomonas aeruginosa) 中的群体感应和 c-di-GMP 抑制剂。
靶点/IC₅₀	Melanocortin Receptor; Apoptosis; Antibiotic
体外研究	Illudin M (0.01-10μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitroTreatment of Mel-Ab cells with Terrein (10-100µM) for 4 days significantly reduces melanin levels in a dose-dependent manner. Terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation.Terrein (5-500µM; 24 and 48 hours) reduces the viability of these cells in concentration- and time-dependent manners.Terrein (150, 250, 500µM; 24 hours) induces programmed cell death in both invasive and non-invasive breast cancer cell lines. Thus, the optimal non-toxic concentrations of Terrein (25 and 75µM) were used for subsequent experiments.Terrein (25 and 75µM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MDA-MB-231 cells. Terrein (75µM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MCF-7 cells.Terrein (75µM) inhibits the expression of RhoA, RhoB, p-Rac1 in MCF-7 cells. Terrein (75µM) inhibits the expression of RhoB,p-Rac1 in MDA-MB-231 cells.Terrein (10, 30, and 100μM) inhibits the production of virulence factors such as elastase, pyocyanin, and rhamnolipid, as well as biofilm formation in P. aeruginosa PAO1 and PA14 strains. Cell Viability Assay
	Cell Line:	MCF-7 and MDA-MB-231 cells
	Concentration:	5, 25, 50, 75, 100, 150, 250, 500µM
	Incubation Time:	24 and 48 hours
	Result:	The IC50s for MCF-7 and MDA-MB-231 cells after 24 h of incubation were 2.34mM and 700µM, respectively. After 48h of incubation, the IC50s are 244.3µM for MCF-7 and 244.5µM for MDA-MB-231 cells.
	Apoptosis Analysis
	Cell Line:	MCF-7 and MDA-MB-231 cells
	Concentration:	25, 75, 150, 250, 500µM
	Incubation Time:	24 hours
	Result:	The percentages of apoptotic cells after 25 and 75µM treatment were 7.52 and 5.82%,respectively for MCF-7 cells (9.94% for the control), and 15.77 and 15.82%,respectively for MDA-MB-231 cells (8.79% for the control).
	RT-PCR
	Cell Line:	MCF-7 and MDA-MB-231 cells
	Concentration:	25, 75µM
	Incubation Time:
	Result:	Decreased the mRNA levels of both MMP-2 and MMP-9 in a concentration-dependent manner.
	Western Blot Analysis
	Cell Line:	MCF-7 and MDA-MB-231 cells
	Concentration:	75µM
	Incubation Time:	6, 12 and 24 hours
	Result:	RhoA and RhoB protein levels were significantly decreased after 6h of 75µM treatment in MCF-7 cells. Phosphorylated (p)-Rac1 was also slightly decreased at 12h.However, RhoC and Cdc42 levels remained unchanged. RhoB protein levels and Rac1 phosphorylation were also decreased in MDA-MB-231 cells at 12 and 24h,respectively.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

搜索质检报告(COA)

参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果