| 中文名称: | 特非那定 | ||||
|---|---|---|---|---|---|
| 英文名称: | Terfenadine | ||||
| 别名: | 特非那丁；叔哌丁醇 (±)-Terfenadine; MDL-991 | ||||
| CAS No: | 50679-08-8 | 分子式: | C32H41NO2 | 分子量: | 471.67 |
| CAS No: | 50679-08-8 | ||||
| 分子式: | C32H41NO2 | ||||
| 分子量: | 471.67 | ||||
| EINEC: | 256-710-8 | ||||
| EINEC: | 256-710-8 | ||||
基本信息
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产品编号： |
T10715 |
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产品名称： |
Terfenadine |
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CAS: |
50679-08-8 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
471.67 |
-20℃ |
1个月 |
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化学名： |
alpha-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol |
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Solubility (25°C)： |
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体外:
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DMSO |
94mg/mL warmed with 50ºC water bath (199.29mM) |
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Ethanol |
27mg/mL warmed with 50ºC water bath (57.24mM) |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.1201mL |
10.6006mL |
21.2013mL |
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5mM |
0.4240mL |
2.1201mL |
4.2403mL |
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10mM |
0.2120mL |
1.0601mL |
2.1201mL |
生物活性
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产品描述 |
一种有效的hERG开放通道抑制剂, IC50为204nM。Terfenadine也是一种H1组胺受体(histamine receptor)拮抗剂，通过调节Ca2+稳态在黑素瘤细胞中起到有效的细胞凋亡诱导作用。 |
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靶点 |
Caspase-4 |
Caspase-2 |
Caspase-9 |
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体外研究 |
Terfenadine ((±)-Terfenadine) (4-20μM;24 hours) induces dose and time-dependent apoptosis on A375 melanoma cells. The IC50 after 24h of TEF treatment in complete medium was 10.4μM for A375 cells,9.9μM for Hs294T cells and 9.6 for HT144 cells.Terfenadine (2-10μM;8 hours) induces dose-dependent cytotoxicity.Terfenadine (10μM;8 hours) causes a massive vacuolization of the cytoplasm and autophagic vacuoles of both double and multiple membranes and at various stages. Terfenadine induces autophagy by ROS-dependent and-independent mechanisms. Apoptosis Analysis |
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Cell Line: |
A375,HT144 and Hs294T cells |
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Concentration: |
4,8,12,16,20μM |
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Incubation Time: |
24 hours |
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Result: |
Induced dose and time-dependent apoptosis. |
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Cell Cytotoxicity Assay |
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Cell Line: |
A375 melanoma cells |
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Concentration: |
2,4,6,8,10μM |
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Incubation Time: |
8 hours |
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Result: |
Induces dose-dependent cytotoxicity. |
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Cell Autophagy Assay |
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Cell Line: |
A375 cells |
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Concentration: |
10μM |
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Incubation Time: |
8 hours |
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Result: |
Caused a massive vacuolization of the cytoplasm and autophagic vacuoles of both double and multiple membranes and at various stages. |
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体内研究 |
Terfenadine (p.o.;40mg/kg;for 16 days) produces a significant inhibition of tumour growth rate and enhances the anticancer effect of EPI in chemo-resistant NSCLC xenograft models. |
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Animal Model: |
6-week-old male BALB/cA-nu mice |
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Dosage: |
40mg/kg |
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Administration: |
P.o.;for 16 days |
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Result: |
Produced a significant inhibition of tumour growth rate. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
