TAS-301 - CAS:193620-69-8 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	TAS-301 促销
英文名称:	TAS-301
别名:	3-Bis-(4-methoxphenyl)methylene-2-indolinone
CAS No:	193620-69-8	分子式:	C₂₃H₁₉NO₃	分子量:	357.4
CAS No:	193620-69-8
分子式:	C₂₃H₁₉NO₃
分子量:	357.4
MDL:	MFCD05865245

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T10033 TAS-301 ≥95% (HPLC) (psaitong)

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包装规格：

2mg 10mg in glass bottle

溶解性：

溶于DMSO（40 mg/mL）

产品描述：

基本信息

产品编号：T10033
产品名称：TAS-301
CAS:	193620-69-8	储存条件	粉末	室温	四年

分子式：	C23H19NO3		溶于液体	-80℃	六个月
分子量：	357.40			-20℃	一个月
化学名：
Solubility (25°C)	体外	DMSO	71mg/mL (198.65mM)
		Ethanol
		Water
	体内（现配现用）
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.7980mL	13.9899mL	27.9799mL
5mM	0.5596mL	2.7980mL	5.5960mL
10mM	0.2798mL	1.3990mL	2.7980mL
50mM	0.0560mL	0.2798mL	0.5596mL

生物活性

产品描述	一种平滑肌细胞迁移和增殖抑制剂.
靶点/IC50	PKC
体外研究	TAS-301 (1-10μM) concentration-dependently inhibits PKC activation and Ca2+influx,induced by PDGF,with 62.7% inhibition on PKC activation at 10μM,and reduces PMA-induced AP-1,with 38% and 67.6% inhibition at 3 and 10μM,respectively.TAS-301 (0.3-3μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB,IGF-1,HB-EGF).TAS-301 (1-10μM) also decreases bFGF-induced BrdU incorporation,especially at 3 and 10μM.
体内研究	TAS-301 (3-100mg/kg,p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury.

推荐实验方法(仅供参考)

细胞实验:

Cell proliferation is determined by the incorporation of BrdU by quiescent cells.SMCs are seeded at 1×104cells/well in 96-well plates in DMEM containing 10% FBS.Two days after the seeding,their growth is arrested for 3 days in a serum-free DMEM containing 5μg/mL insulin,5μg/mL transferrin and 5ng/mL sodium selenium (ITS).Then,the DMEM/ITS is removed,and serum-free DMEM containing 0.1% BSA with or without TAS-301 or tranilast is added to the quiescent cells 2hr before treatment with the growth factor (i.e.,bFGF 0.1ng/mL).At 24hr after stimulation,BrdU (10μM) is added to the cells;24hr later,the cells are fixed.An ELISA is used to detect and to quantify the incorporated BrdU (n=6).The drugs are present during the entire experiment.

动物实验:

Rats

On the 14th day after the balloon injury,the rats are anesthetized with ether so as to avoid any stress to the animals and then perfused transcardially with saline,followed by 10% buffered formalin.Next,the left carotid artery (length from aortic arch to bifurcation) is removed,postfixed and embedded in paraffin.Then,3-μm-thick artery sections (six sections for each artery) are cut and stained with hematoxylin and eosin.The cross-sectional areas of the intima and the media on photographs are measured by use of a digital analyzer.The average of the ratio of the intimal area to the medial area in each artery is determined.Experimental groups are as follows:Vehicle (n=9),TAS-301 (3,10,30 and 100mg/kg,n=9) and tranilast (100 and 300mg/kg,n=9).The data on two rats (one in TAS-301 100mg/kg group and one in tranilast 100mg/kg group) is omitted from the evaluation because of death due to faulty oral administration.

保存条件：

室温

UN码：

HazardClass：

危害声明：

安全说明：

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