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中文名称: 盐酸妥布特罗
英文名称: Tulobuterol Hydrochloride
CAS No: 56776-01-3
分子式: C12H19Cl2NO
分子量: 264.19
安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF) 点击下载技术规格说明书(PDF)
T0541 盐酸妥布特罗 ≥98% (psaitong)
包装规格：
100mg in glass bottle
溶解性：
溶于DMSO（50 mg/mL 超声)
产品描述：

基本信息

产品编号：

T0541 

产品名称：

Tulobuterol hydrochloride

CAS:

56776-01-3

 

储存条件

粉末

-20℃

四年

 

 

分子式：

C12H19Cl2NO

溶于液体

-80℃

6个月

分子量

264.19

-20℃

1个月

化学名： 

2-(tert-butylamino)-1-(2-chlorophenyl)ethanol;hydrochloride

Solubility (25°C)：

 

体外:

 

DMSO

53mg/mL (200.61mM)

Ethanol

10mg/mL (37.85mM)

Water

53mg/mL (200.61mM)

体内(现配现用):

 

＜1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

3.7852mL

18.9258mL

37.8515mL

5mM

0.7570mL

3.7852mL

7.5703mL

10mM

0.3785mL

1.8926mL

3.7852mL

50mM

0.0757mL

0.3785mL

0.7570mL

 

生物活性

产品描述

一种长效的 β2 肾上腺素受体激动剂，可减少慢性阻塞性肺疾病和支气管哮喘的发作频率。

靶点

β2-adrenoceptor

 

体外研究

Tulobuterol (0.1μM;24 hours or 72 hours; human tracheal epithelial cells) treatment decreases the RV14 RNA levels at 1 day and at 3 days after infection.The concentrations of sICAM-1 in the supernatants of the cells treated with tulobutero are significantly lower than those in the cells treated with vehicle before RV14 infection.Treatment with tulobuterol reduces the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells.Also reduces the RV14 infection-induced secretion of IL-1β,IL-6,and IL-8.Tulobuterol treatment produces a small but significant reduction in the amount of p50,p65,and c-Rel of NF-κB induced by RV14 infection.

RT-PCR

Cell Line:

Human tracheal epithelial cells infected with RV14

Concentration:

0.1μM

Incubation Time:

24 hours or 72 hours

Result:

Decreased the RV14 RNA levels at 1 day and at 3 days after infection.The concentrations of sICAM-1 in the supernatants of the cells were significantly lower.Reduced the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells.Also reduced the RV14 infection-induced secretion of IL-1β,IL-6,and IL-8.And produced a small but significant reduction in the amount of p50,p65,and c-Rel of NF-κB induced by RV14 infection.

体内研究

In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice;21.7±0.2g) treated with Endotoxin.Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after E.coli endotoxin (20mg/kg) administration are measured.E0 and E4 diaphragm muscles are analyzed at 0,12,and 24h after transdermal Tulobuterol treatment.The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other,indicating that Tulobuterol patch restores the muscle contractility.Thus,diaphragm muscle contractility is maintained during 4h of endotoxin administration with Tulobuterol patch for over 24h.
保存条件：
-20℃
UN码：
HazardClass：
危害声明：
安全说明：
搜索质检报告(COA)
参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • =
    *
    *
    *选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
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