| 中文名称: | 异冬谷酸 | ||||
|---|---|---|---|---|---|
| 英文名称: | Spaglumic Acid | ||||
| 别名: | (S)-2-((S)-2-乙酰氨基-3-羧基丙酰胺基)戊二酸 N-Acetylaspartylglutamic acid； N-Acetyl-Asp-Glu | ||||
| CAS No: | 3106-85-2 | 分子式: | C11H16N2O8 | 分子量: | 304.25 |
| CAS No: | 3106-85-2 | ||||
| 分子式: | C11H16N2O8 | ||||
| 分子量: | 304.25 | ||||
包装规格：
10mg in glass bottle
溶解性：
溶于水(50mg/mL)
产品描述：
一种在脑中以毫摩尔浓度存在的神经肽。
α-NAAG is a peptide neurotransmitter that is widely expressed throughout mammalian central and peripheral nervous systems. Following synaptic release, α-NAAG activates postsynaptic metabotropic glutamate receptor 3 (mGluR3) to inhibit cAMP production in neurons and astrocytes, as well as acts on presynaptic mGluR3 to inhibit the release of amine neurotransmitters, including GABA and glutamate. Increasing α-NAAG levels via NAAG peptidase inhibition reduces trauma-induced excitotoxic cell death in a mouse model of traumatic brain injury, as well as reduces hyperalgesia in various rodent pain models and schizophrenia-like stereotypic behaviors induced by phencyclidine in rats. Tumor levels of α-NAAG are positively correlated with tumor grade in patients with gliomas and meningiomas.
α-NAAG is a peptide neurotransmitter that is widely expressed throughout mammalian central and peripheral nervous systems. Following synaptic release, α-NAAG activates postsynaptic metabotropic glutamate receptor 3 (mGluR3) to inhibit cAMP production in neurons and astrocytes, as well as acts on presynaptic mGluR3 to inhibit the release of amine neurotransmitters, including GABA and glutamate. Increasing α-NAAG levels via NAAG peptidase inhibition reduces trauma-induced excitotoxic cell death in a mouse model of traumatic brain injury, as well as reduces hyperalgesia in various rodent pain models and schizophrenia-like stereotypic behaviors induced by phencyclidine in rats. Tumor levels of α-NAAG are positively correlated with tumor grade in patients with gliomas and meningiomas.
保存条件：
-20℃
UN码：
HazardClass：
危害声明：
安全说明：
搜索质检报告(COA)
参考文献 & 客户发表文献
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
