| 中文名称: | Se-(甲基)硒基-L-半胱氨酸 | ||||
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| 英文名称: | Se-Methylselenocysteine | ||||
| 别名: | Se-(甲基)硒基-L-半胱氨酸 Methylselenocysteine; Se-Methylseleno-L-cysteine | ||||
| CAS No: | 26046-90-2 | 分子式: | C4H9NO2Se | 分子量: | 182.08 |
| CAS No: | 26046-90-2 | ||||
| 分子式: | C4H9NO2Se | ||||
| 分子量: | 182.08 | ||||
| MDL: | MFCD00800565 | EINEC: | 5465 | ||
| EINEC: | 5465 | ||||
基本信息
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产品编号：S60007 |
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产品名称：Se-Methylselenocysteine |
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CAS: |
26046-90-2 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
182.08 |
-20℃ |
一个月 |
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化学名： |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内（现配现用） |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
5.4921mL |
27.4605mL |
54.9209mL |
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5mM |
1.0984mL |
5.4921mL |
10.9842mL |
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10mM |
0.5492mL |
2.7460mL |
5.4921mL |
生物活性
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产品描述 |
甲基硒的前体，具有强大的癌症化学预防活性和抗氧化活性。Se-Methylselenocysteine 具有口服生物活性，可诱导细胞凋亡 (apoptosis)。 |
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靶点/IC50 |
Apoptosis |
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体外研究 |
Se-Methylselenocysteine (100-400μM; 3 days) induces apoptosis in SKOV-33 cells.Se-Methylselenocysteine (100-400μM; 3 days) induces caspase-3 mediated apoptosis. Apoptosis Analysis |
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Cell Line: |
SKOV-3 cells |
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Concentration: |
100, 200, 400μM |
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Incubation Time: |
3 days |
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Result: |
Resulted in a markedly increased accumulation of Sub-G1 phase, which occurred in both SeMSC concentration and culture time-dependent. |
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Western Blot Analysis |
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Cell Line: |
SKOV-3 cells |
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Concentration: |
100, 200, 400μM |
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Incubation Time: |
3 days |
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Result: |
Resulted in a decrease in the expression of the 32 kDa form of procaspase-3. |
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体内研究 |
Se-Methylselenocysteine (0.2mg/mouse; p.o.; daily for 14 days) potentiates the antitumour activity of CDDP and Cyclophosphamide in nude mice bearing human FaDu and A253 head and neck xenografts.Alzheimer's disease (AD) mice are treats with Se Methylselenocysteine (0.75mg/kg BW per day) in their drinking water for 10 months. Se-Methylselenocysteine reduces oxidative stress and neuro-inflammation; Se-Methylselenocysteine modulates the distribution and levels of several metal ions; Se-Methylselenocysteine decreases amyloid-β peptide (Aβ) generation by inhibiting the expression of its precursor protein APP and β-secretase (BACE1), and attenuates tau hyperphosphorylation and neurofibrillary tangles (NFT) formation via promoting protein phosphatase 2A (PP2A) activity,thereby preserving synaptic proteins and neuron activities and finally improving spatial learning and memory deficits in AD model mice. |
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Animal Model: |
Female athymic nude mice (bearing human A253 and FaDu squamous cell carcinoma xenografts) |
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Dosage: |
0.2mg/mouse |
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Administration: |
p.o.; daily for 14 days (7 days before and 7 days after Cyclophosphamide or CDDP in a total of 14 days) |
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Result: |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
