| 中文名称: | SLC13A5-IN-1 | ||||
|---|---|---|---|---|---|
| 英文名称: | SLC13A5-IN-1 | ||||
| 别名: | N-(4-Chlorobenzyl)-1-((3,5-dichlorophenyl)sulfonyl)piperidine-4-carboxamide;SCHEMBL20258718 | ||||
| CAS No: | 2227548-95-8 | 分子式: | C19H19Cl3N2O3S | 分子量: | 461.79 |
| CAS No: | 2227548-95-8 | ||||
| 分子式: | C19H19Cl3N2O3S | ||||
| 分子量: | 461.79 | ||||
包装规格：
1mg 5mg 10mg 25mg 50mg 100mg in glass bottle
产品简介：
SLC13A5-IN-1 是一种选择性柠檬酸钠协同转运蛋白 (SLC13A5) 抑制剂。SLC13A5-IN-1 完全阻断 HepG2 细胞摄取 14C-柠檬酸，IC50 值为 0.022 μM。SLC13A5-IN-1 可以用于研究代谢和/或心血管疾病的研究。SLC13A5-IN-1 源于专利 WO2018104220A1，化合物 I-5。
储备液保存：
-80°C 6 months
-20°C 1 month
-20°C 1 month
靶点：
IC50: 0.022 μM (HepG2/14C-Citrate Uptake Assay); 0.056 μM (recombinant hSLC3A5/14C-Citrate Uptake Assay)
体外研究：
SLC13A5-IN-1 exhibits an IC50 of 0.022 μM in HepG2/14C-Citrate Uptake Assay. HepG2 cells endogenously express hSLC13A5 transporter which is responsible for the uptake of citrate into these cells. Uptake of 14C-citrate can be completely blocked by SLC13A5-IN-1 and the signal can be competed with unlabelled citrate. T.
SLC13A5-IN-1 exhibits an IC50 of 0.056 μM in recombinant hSLC3A5/14C-Citrate Uptake Assay.
SLC13A5-IN-1 exhibits an IC50 of 100 μM in recombinant Human GlyT2/3H-Glycine Uptake Assay. The human embryonic kidney 293 cells are used that stably over-express the human GlyT2 receptor which is responsible for the uptake of glycine into these cells. Uptake of 3H-glycine can be completely blocked by SLC13A5-IN-1.
SLC13A5-IN-1 exhibits an IC50 of 0.056 μM in recombinant hSLC3A5/14C-Citrate Uptake Assay.
SLC13A5-IN-1 exhibits an IC50 of 100 μM in recombinant Human GlyT2/3H-Glycine Uptake Assay. The human embryonic kidney 293 cells are used that stably over-express the human GlyT2 receptor which is responsible for the uptake of glycine into these cells. Uptake of 3H-glycine can be completely blocked by SLC13A5-IN-1.
注意事项：
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2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
保存条件：
-20°C
UN码：
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