| 中文名称: | SR-31747 free base | ||||
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| 英文名称: | SR-31747 free base | ||||
| 别名: | 3-(3-chloro-4-cyclohexylphenyl)-n-cyclohexyl-n-ethyl-2(z)-propenylamine | ||||
| CAS No: | 132173-06-9 | 分子式: | C23H34ClN | 分子量: | 359.98 |
| CAS No: | 132173-06-9 | ||||
| 分子式: | C23H34ClN | ||||
| 分子量: | 359.98 | ||||
基本信息
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产品编号： |
S11211 |
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产品名称： |
SR-31747 free base |
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CAS: |
132173-06-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量 |
359.98 |
-20℃ |
1个月 |
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化学名： |
3-(3-chloro-4-cyclohexylphenyl)-n-cyclohexyl-n-ethyl-2(z)-propenylamine |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.7779mL |
13.8897mL |
27.7793mL |
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5mM |
0.5556mL |
2.7779mL |
5.5559mL |
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10mM |
0.2778mL |
1.3890mL |
2.7779mL |
生物活性
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产品描述 |
一种具有免疫抑制和抗炎特性的 sigma 配体。SR-31747 free base 通过抑制固醇异构酶来阻止细胞增殖。 |
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靶点 |
Sigma ligand |
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体外研究 |
SR-31747 blocks the proliferation of lymphocytes at a concentration of 10nM.SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24h after activation.SR-31747 arrests proliferation in yeast cells in a dose-dependent manner. |
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体内研究 |
In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1,IL-6 and TNF-α in a dose-dependent manner (ED50,2mg/kg).SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids.This conclusion was supported by in vivo experiments that shows that:1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747;2) administration of SR-31747 induces an enhancement of the corticosterone level.SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition. |
推荐实验方法(仅供参考)
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动物实验: |
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IL-1,IL-6 and TNF-a are induced by i.p.injection of LPS into BALBIc mice.SR 31747 or reference substances are administered i.p.at the indicated doses together with LPS (0.5mg/kg).Control animals are treated with LPS and vehicle.Blood samples are collected from the retro-orbital sinus 1hr or 4hr after LPS injection for the determination of TNF-α,IL-1 and IL-6. Plasma is prepared and stored frozen until experiments.The IL-1 plasma level is determined by a competitive radioreceptor assay with the use of the murine NOBEL4 cell line and [125I]-IL-1.The IL-6 assay is conducted with the B9 murine IL-6-dependent cell line.The TNF-a plasma level is evaluated by the cytolytic assay with the dactinomycin-treated LM6 cell line,derived from the murine fibroblastic L929 cell line.Each determination is performed on a pool of three different plasma samples.None of the molecules administered affect these assays even at the highest dose (10-5 M),which thereby rules out the possibility of any direct effect caused by the presence ofdrugs in treated-animal sera. In the various tests, one unit is defined as the amount of cytokines able to induce 50% of the maximal effect. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
