SUN11602 - CAS:704869-38-5 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	SUN11602
英文名称:	SUN11602
别名:	SUN11602 4-((4-(2-((4-Amino-2,3,5,6-tetramethylphenyl)amino)-N-methylacetamido)piperidin-1-yl)methyl)benzamide
CAS No:	704869-38-5	分子式:	C₂₆H₃₇N₅O₂	分子量:	451.60428
CAS No:	704869-38-5
分子式:	C₂₆H₃₇N₅O₂
分子量:	451.60428

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S11104 SUN11602 ≥98% (psaitong)

相关产品

包装规格：

5mg 10mg 25mg 50mg 100mg in glass bottle

溶解性：

溶于DMSO（≥37mg/mL）

产品描述：

基本信息

产品编号：S11104

产品名称：SUN11602

CAS:

704869-38-5

储存条件

粉末

-20℃

四年

分子式：

C26H37N5O2

溶于液体

-80℃

两年

分子量

451.60

化学名：

Solubility (25°C)

体外

DMSO

90mg/mL warmed with 50ºC water bath (199.29mM)

Ethanol

31mg/mL warmed with 50ºC water bath (68.64mM)

Water

Insoluble

体内（现配现用）

＜1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.2143mL	11.0717mL	22.1435mL
5mM	0.4429mL	2.2143mL	4.4287mL
10mM	0.2214mL	1.1072mL	2.2143mL
50mM	0.0443mL	0.2214mL	0.4429mL

生物活性

产品描述

一种新型的碱性苯胺化合物，具有成纤维细胞生长因子活性。

靶点/IC₅₀

bFGF

体外研究

SUN11602 prevents glutamate-induced neuronal death in primary cultures of rat cerebrocortical neurons. SUN11602 increases the levels of CALB1 gene expression in cerebrocortical neurons.SUN11602 exerts protective effects on hippocampal neurons through activation of FGFR1 and increases CalB expression. SUN11602 promotes neurite outgrowth of primarily cultured rat hippocampal neurons.

体内研究

In WT mice, SUN11602 increases the levels of newly synthesized Calb in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca2+. This Ca2+-capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate. Oral administration of SUN11602 at the midpoint of Aβ1-40 and ibotenate injections attenuate short-term memory impairment in the Y-maze test, as well as spatial learning deficits in the water maze task. In addition, the SUN11602 treatment inhibits the increase of peripheral-type benzodiazepine-binding sites (PTBBS),which are a marker for gliosis.

推荐实验方法(仅供参考)

细胞实验:

Cerebrocortical neurons are pretreated with vehicle (Hanks’Balanced Salt Solution),SUN11602,bFGF, or the other growth factors for 24h prior to the onset of glutamate toxicity.Subsequently,10μL of the MTT solution (5mg/mL) is added to each well (200μL of culture medium) of the microplates. Neurons in each well are then dried for 24h, and 200μL of DMSO is poured into all of the wells in order to dissolve the reaction products thoroughly for the MTT assay.

动物实验:
Rats: SUN11602 (0.1,1,and10mg/kg)is administered orally to the rat hippocampal-lesion model,once at 24h after the A β1–40 injection. In the vehicle-treated groups, saline is administered instead of SUN11602.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果