| 中文名称: | Sorbinil | ||||
|---|---|---|---|---|---|
| 英文名称: | Sorbinil | ||||
| 别名: | Sorbinil (+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione, (4S)-6-Fluoro-2,3-dihydro-spiro[4H-1-benzopyran-4,4′-imidazolidine]-2′,5′-dione | ||||
| CAS No: | 68367-52-2 | 分子式: | C11H9FN2O3 | 分子量: | 236.2 |
| CAS No: | 68367-52-2 | ||||
| 分子式: | C11H9FN2O3 | ||||
| 分子量: | 236.2 | ||||
一种醛糖还原酶抑制剂(ARI)。Sorbinil可用于糖尿病和糖尿病并发症方的研究，降低AR活性和抑制多元醇途径，发现它比人类使用的其它ARI更安全。
Sorbinil, also known as CP-45634, is an aldose reductase inhibitor potentially for the treatment of diabetes. Aldose reductase is an enzyme present in lens and brain that gets rid of excess glucose by converting it to sorbitol. Sorbitol accumulation can lead to the development of cataracts in the lens and neuropathy in peripheral nerves. Sorbinil has been shown to inhibit aldose reductase in human brain and placenta and calf and rat lens. Sorbinil reduced sorbitol accummulation in rat lens and sciatic nerve of diabetic rats orally administered 0.25mg/kg sorbinil.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
