| 中文名称: | SN2 | ||||
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| 英文名称: | SN2 | ||||
| 别名: | D-3263 hydrochloride D-3263 hydrochloride | ||||
| CAS No: | 823218-99-1 | 分子式: | C17H21NO | 分子量: | 255.35 |
| CAS No: | 823218-99-1 | ||||
| 分子式: | C17H21NO | ||||
| 分子量: | 255.35 | ||||
基本信息
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产品编号： |
S10990 |
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产品名称： |
SN2 |
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CAS: |
823218-99-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
255.35 |
-20℃ |
1个月 |
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化学名： |
3a,4,5,6,7,7a-Hexahydro-3-(2,4,6-trimethylphenyl)-4,7-methano-1,2-benzisoxazole |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
I |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.9162mL |
19.5810mL |
39.1619mL |
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5mM |
0.7832mL |
3.9162mL |
7.8324mL |
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10mM |
0.3916mL |
1.9581mL |
3.9162mL |
生物活性
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产品描述 |
一种有效的TRPML3离子通道激活剂。 |
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靶点 |
EC50:1.8±0.13μM (TRPML3),>29.9μM (TRPML1) |
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体外研究 |
The conductance of TRPML3 channels is estimate, when activated with 10µM SN-2 is approximately 10pS at −80mV.TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS),with compound in ELS,and finally with ELS alone.Two representative compounds,SF-24 and SN-2,are tested.SF-24 is one of the least effective compounds,and SN-2 is one of the most active ones.SN-2 has a similar synergistic effect,also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses,reaching average current densities of up to 3nA/pF at −80mV.Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes,suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K).Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
