| 中文名称: | SX-3228 | ||||
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| 英文名称: | SX-3228 | ||||
| 别名: | SX-3228 SX-3228 | ||||
| CAS No: | 156364-04-4 | 分子式: | C18H18N4O3 | 分子量: | 338.36 |
| CAS No: | 156364-04-4 | ||||
| 分子式: | C18H18N4O3 | ||||
| 分子量: | 338.36 | ||||
基本信息
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产品编号： |
S10951 |
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产品名称： |
SX-3228 |
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CAS: |
156364-04-4 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
二年 |
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分子量： |
338.36 |
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化学名： |
6-BENZYL-3-(5-METHOXY-1,3,4-OXADIAZOL-2-YL)-1,5,7,8-TETRAHYDRO-1,6-NAPHTHYRIDIN-2-ONE |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种选择性苯二氮卓类(benzodiazepine1，BZ1)受体激动剂 |
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靶点 |
IC50:17nM (BZ1 receptor) |
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体外研究 |
SX-3228 is a selective ligand for the BZ1 receptor.Among the BZ-receptor subtypes,SX-3228 preferentially binds to the BZ1 receptor (IC50=17nM).It has very weak affinity for the BZ2 receptor (spinal cord: IC50=127nM),and virtually no affinity for the peripheral type BZ receptor (kidney:IC50>10000nM).A compound with similar selectivity,SX-3228 has been shown to bind to BZ receptors,but not to dopamine (D1,D2),serotonin (5-HT1,5-HT2 and 5-HT3 subtypes),noradrenaline (α1,α2,β),GABA or acetylcholine (muscarinic) subtypes. |
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体内研究 |
Administration of 0.5-2.5mg/kg SX-3228 to rats during the light phase induces a significant reduction of rapid-eyemovement sleep (REMS) (P<0.05) during the third recording hour.Administration of SX-3228 (0.5-2.5mg/kg) at the beginning of the dark period significantly and dose-dependently reduces waking (W) and increases slow wave sleep (SWS) during the 6-h recording period (P<0.05-0.01);however,significant changes during the last recording hour are restricted to the 2.5mg/kg dose (P<0.01). |
推荐实验方法(仅供参考)
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动物实验: |
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Rats Twelve male Wistar rats (350-380g) are used.Subcutaneous (sc) injections are given in a final volume of 1.0mL/kg.All rats are given the corresponding volume of control solution (saline+Tween-80) in the control sessions. Following sc injection,a 6-h sleep recording is started at approximately 8:00 a.m.At least 4 days are allowed to elapse between injections to avoid long-lasting and rebound effects on sleep.The effects of SX-3228 0.5-2.5mg/kg are studied in one group of animals (N=6) during the light phase of the 12-h light:12-h dark cycle,starting 1h after the beginning of the light period.Polysomnographic recordings are started immediately after control solution or drug administration. Each rat receives all four treatments (control,and 0.5,1.0,2.5mg/kg SX-3228). |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
