中文名称: | SUN 1334H | ||||
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英文名称: | SUN 1334H | ||||
CAS No: | 607736-84-5 | 分子式: | C23H28Cl2F2N2O3 | 分子量: | 489.38 |
CAS No: | 607736-84-5 | ||||
分子式: | C23H28Cl2F2N2O3 | ||||
分子量: | 489.38 |
基本信息
产品编号: |
S10902 |
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产品名称: |
SUN 1334H |
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CAS: |
607736-84-5 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
489.38 |
-20℃ |
1个月 |
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化学名: |
{4-[4-[Bis-(4-fluorophenyl)methyl]piperizin-1-yl]-(E)-but-2-enyloxy}acetic Acid Dihydrochloride |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
一种有效的,可口服的,选择性的 H1 receptor 拮抗剂,Ki 值为 9.7nM。 |
靶点 |
Ki:9.7nM (H1 receptor) |
体外研究 |
SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC50 (half the maximal inhibitory concentration) of 0.198μM.In CHO-K1/hERG cells,SUN-1334H does not modulate hERG K+-currents at concentrations as high as 100μM.SUN-1334H,cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes,IL-4 and total protein concentrations. |
体内研究 |
SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs.In skin allergy models,SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions.In central nervous system side effects models,SUN-1334H,desloratadine and fexofenadine are devoid of any significant effects. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )