| 中文名称: | SC-560 | ||||
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| 英文名称: | SC-560 | ||||
| CAS No: | 188817-13-2 | 分子式: | C17H12ClF3N2O | 分子量: | 352.74 |
| CAS No: | 188817-13-2 | ||||
| 分子式: | C17H12ClF3N2O | ||||
| 分子量: | 352.74 | ||||
基本信息
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产品编号： |
S10892 |
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产品名称： |
SC-560 |
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CAS: |
188817-13-2 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
352.74 |
-20℃ |
1个月 |
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化学名： |
5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole |
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Solubility (25°C)： |
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体外:
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DMSO |
70mg/mL (198.44mM) |
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Ethanol |
70mg/mL (198.44mM) |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.8349mL |
14.1747mL |
28.3495mL |
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5mM |
0.5670mL |
2.8349mL |
5.6699mL |
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10mM |
0.2835mL |
1.4175mL |
2.8349mL |
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50mM |
0.0567mL |
0.2835mL |
0.5670mL |
生物活性
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产品描述 |
一种有效，选择性的COX-1抑制剂。 |
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靶点 |
COX-1 |
COX-2 |
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9nM |
6.3μM |
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体外研究 |
Preincubation of COX-1 with SC-560 inhibits the conversion of arachidonic acid to PGE2 in a concentration-dependent manner.The IC50 of SC-560 for COX-2 is 6.3μM,nearly 1,000-fold higher than with COX-1.SC-560 shows a dose and time dependent inhibitory effect on HCC cell growth.SC-560 also inhibits colony formation in soft agar and induces apoptosis in HCC cells in a dose-dependent manner.Moreover,SC-560 decreases the levels of the anti-apoptotic proteins survivin and XIAP and activates caspase 3 and 7 in a dose and time dependent fashion. |
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体内研究 |
Oral dosing with either 10 or 30mg/kg SC-560 1 hour before assay completely inhibits ionophore-stimulated TxB2production,indicating that SC-560 is orally bioavailable and inhibits COX-1 in vivo.SC-560 extensively distributes into rat tissues,and has a CL approaching hepatic plasma flow.The drug displays low less than 15% and formulation dependent bioavailability after oral administration and demonstrates kidney toxicity. |
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推荐实验方法(仅供参考)
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细胞实验: |
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HuH-6 and HA22T/VGH cells (5000/well) are treated with various concentrations of SC-560 (5,10,25,50,100,200μM) and cultured for 72h.At the end of treatment,cell viability is assessed by MTS assay. |
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动物实验: |
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Rats:The pharmacokinetics of SC-560 is studied in Sprague-Dawley rats after a single intravenous (i.v.) and oral dose (10mg/kg) in polyethylene glycol (PEG) 600 and a single oral dose (10mg/kg) in 1% methylcellulose (MC).Serial blood samples are collected via a catheter inserted in the right jugular vein and serum samples are analysed for SC-560 using reverse phase HPLC.After oral administration of SC-560 in PEG,urine is also collected for 24h and analyzed for urinary sodium,chloride,and potassium as well as NAG. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
