| 中文名称: | 盐酸舒必利 | ||||
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| 英文名称: | Sultopride hydrochloride | ||||
| 别名: | 盐酸舒托必利 LIN-1418 hydrochloride | ||||
| CAS No: | 23694-17-9 | 分子式: | C17H27ClN2O4S | 分子量: | 390.93 |
| CAS No: | 23694-17-9 | ||||
| 分子式: | C17H27ClN2O4S | ||||
| 分子量: | 390.93 | ||||
| EINEC: | 245-829-0 | ||||
| EINEC: | 245-829-0 | ||||
基本信息
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产品编号： |
S10860 |
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产品名称： |
Sultopride hydrochloride |
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CAS: |
23694-17-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
390.93 |
-20℃ |
1个月 |
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化学名： |
N-[(1-乙基-2-吡咯烷基)甲基]-5-(乙基磺酰)-2-甲氧基苯甲酰胺盐酸盐 LIN-1418 hydrochloride |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.5580mL |
12.7900mL |
25.5800mL |
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5mM |
0.5116mL |
2.5580mL |
5.1160mL |
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10mM |
0.2558mL |
1.2790mL |
2.5580mL |
生物活性
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产品描述 |
一种多巴胺 D2 受体的选择性拮抗剂。 |
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靶点 |
Dopamine D2 receptor |
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体内研究 |
Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective antagonist of dopamine D2 receptor.DOPAC and HVA levels in the striatum,the nucleus accumbens and the medial prefrontal cortex are higher in the rats treated with Sultopride hydrochloride and sulpiride than those of the controls. In the striatum,DOPAC and HVA levels are higher in the Sultopride hydrochloride-treated rats than the sulpiride-treated rats (p<0.05).In the nucleus accumbens,DOPAC levels are higher in the Sultopride hydrochloride-treated rats than sulpiride treated rats (p<0.05).In the Sultopride hydrochloride-treated rats,DOPAC and HVA levels are higher in the striatum or in the nucleus accumbens than in the medial prefrontal cortex (p<0.05). |
推荐实验方法(仅供参考)
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动物实验: |
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Thirty-six male Sprague-Dawley rats weighing 180 to 220g are used in this study.The rats are divided into three groups of 6 each.One group is intraperitoneally injected with Sultopride hydrochloride (100mg/kg body weight), the second group with sulphide (100mg/kg body weight),and the third group with normal saline.One hundred minutes after the initial treatments,apomorphine (0.1mg/kg body weight,dissolved in saline ad libitum) is administered subcutaneously to the three groups,and 20 minutes later the rats are sacrificed.The third group serves as controls. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
