| 中文名称: | 盐酸螺哌隆 | ||||
|---|---|---|---|---|---|
| 英文名称: | Spiperone hydrochloride | ||||
| 别名: | 盐酸螺哌隆 Spiperone hydrochloride | ||||
| CAS No: | 2022-29-9 | 分子式: | C23H27ClFN3O2 | 分子量: | 431.93 |
| CAS No: | 2022-29-9 | ||||
| 分子式: | C23H27ClFN3O2 | ||||
| 分子量: | 431.93 | ||||
基本信息
|
产品编号： |
S10817 |
||||
|
产品名称： |
Spiperone hydrochloride |
||||
|
CAS: |
2022-29-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
|
|
|
||||
|
分子式： |
溶于液体 |
-80℃ |
6个月 |
||
|
分子量： |
431.93 |
-20℃ |
1个月 |
||
|
化学名： |
8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;hydrochloride |
||||
|
Solubility (25°C)： |
|||||
|
体外:
|
DMSO |
|
|||
|
Ethanol |
|
||||
|
Water |
|
||||
|
体内(现配现用): |
|
||||
|
＜1mg/ml表示微溶或不溶。 |
|||||
|
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
|||||
|
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
|||||
制备储备液
|
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
|
1mM |
2.3152mL |
11.5759mL |
23.1519mL |
|
5mM |
0.4630mL |
2.3152mL |
4.6304mL |
|
10mM |
0.2315mL |
1.1576mL |
2.3152mL |
生物活性
|
产品描述 |
一种选择性的多巴胺 D2 受体 (D2，D3，D4，D1 和 D5 受体的 Ki 值分别为 0.06nM，0.6nM，0.08nM，~350nM，~3500nM) 和 5-HT2A/5-HT1A 受体 (Ki 为1nM/49nM) 拮抗剂。Spiperone hydrochloride 也是一种选择性的 α1B-肾上腺素受体 (α1B-adrenoceptor) 拮抗剂。Spiperone hydrochloride 激活钙激活的氯离子通道 (CaCC)。抗精神病和抗炎作用。 |
||||
|
靶点 |
Dopamine Receptor |
5-HT Receptor |
Adrenergic Receptor |
Chloride Channel |
|
|
体外研究 |
Spiperone is a potent intracellular Ca2+ enhancer (EC50=9.3μM) and stimulates intracellular Ca2+through a protein tyrosine kinase-coupled phospholipase C-dependent pathway,which results in increased secretion of Cl-in Calu-3 and CFBE41o-cell monolayers.Spiperone significantly decreases the production of nitric oxide in lipopolysaccharide-stimulated BV-2 microglia cells,primary microglia and primary astrocyte cultures.Spiperone also significantly inhibits nitric oxide production in ATPstimulated primary microglia cultures.Spiperone markedly decreases the production of TNF-α in BV-2 microglia cells.Spiperone attenuates the expression of inducible nitric oxide synthase and proinflammatory cytokines such as IL-1β and TNF-α at mRNA levels in BV-2 microglia cells. |
||||
|
体内研究 |
Spiperone (1.5mg/kg;intraperitoneal injection;on days 1,3,6,7,and 13-21;C57Bl/6 mice) treatment reduces infiltration of the alveolar interstitium and alveolar ducts with inflammatory cells and prevents the growth of the connective tissue in the parenchyma of Bleomycin lungs. |
||||
|
Animal Model: |
C57Bl/6 mice (7-8-week-old) induced pulmonary fibrosis by Bleomycin |
||||
|
Dosage: |
1.5mg/kg |
||||
|
Administration: |
Intraperitoneal injection;on days 1,3,6,7,and 13-21 |
||||
|
Result: |
Reduced infiltration of the alveolar interstitium and alveolar ducts with inflammatory cells and prevented the growth of the connective tissue in the parenchyma of bleomycin lungs. |
||||
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
