中文名称: | SW106065 促销 | ||||
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英文名称: | SW106065 | ||||
CAS No: | 62289-81-0 | 分子式: | C10H8N2Os | 分子量: | 204.25 |
CAS No: | 62289-81-0 | ||||
分子式: | C10H8N2Os | ||||
分子量: | 204.25 |
基本信息
产品编号:S10725 |
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产品名称:SW106065 |
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CAS: |
62289-81-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
204.25 |
-20℃ |
一个月 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内(现配现用) |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
4.8960mL |
24.4798mL |
48.9596mL |
5mM |
0.9792mL |
4.8960mL |
9.7919mL |
10mM |
0.4896mL |
2.4480mL |
4.8960mL |
生物活性
产品描述 |
一种恶性周围神经鞘瘤 (MPNST) 的凋亡 (apoptosis) 诱导剂。 |
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靶点/IC50 |
Apoptosis |
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体外研究 |
SW106065 (Compound 21, Cpd21) inhibits the human MPNST cell lines growth in a dose dependent manner, and EC50 concentrations of 439nM and 753.6nM for S462 and SNF96.2 cells,respectively. SW106065 remains nontoxic to normally dividing Schwann cells or mouse embryonic fibroblasts.SW106065 (Cpd21; 0.25-5µM; 24 hours; sMPNST cells) treatment shows a decreased percentage of cells in S phase, and a corresponding increased percentage in G1/G0 and G2/M.SW106065 (Cpd21;0.25-5µM; 24 hours; sMPNST cells) treatment decreases the levels of cyclin A2, cyclin B1, cyclin D1, cyclin E, cdk4, and cdk6. And increases levels of cdkn1a and cdkn2a mRNA were observed in a dose-dependent manner.SW106065 (Cpd21;0.25-5µM; 24 hours;sMPNST cells) treatment decreases the levels of Cyclin D1 protein.SW106065 (Cpd21) treatment significant increase in the percentage of apoptotic cells. |
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Cell Line: |
sMPNST cells |
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Concentration: |
0.25µM, 0.5µM, 1µM, 2.5µM, and 5µM |
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Incubation Time: |
24 hours |
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Result: |
Showed a decreased percentage of cells in S phase, and a corresponding increased percentage in G1/G0 and G2/M. |
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RT-PCR |
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Cell Line: |
sMPNST cells |
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Concentration: |
0.25µM, 0.5µM, 1µM, 2.5µM, and 5µM |
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Incubation Time: |
24 hours |
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Result: |
Decreased levels of cyclin A2, cyclin B1, cyclin D1, cyclin E, cdk4, and cdk6.Increased levels of cdkn1a and cdkn2a mRNA were observed in a dose-dependent manner. |
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Western Blot Analysis |
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Cell Line: |
sMPNST cells |
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Concentration: |
0.25µM, 0.5µM, 1µM, 2.5µM, and 5µM |
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Incubation Time: |
24 hours |
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Result: |
Decreased levels of Cyclin D1 protein. |
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体内研究 |
SW106065 (Cpd21; 40mg/kg; intraperitoneal injection; twice per day for 4 weeks) treatment can be delivered to mice in concentrations to sufficiently penetrate sMPNST tissue, and inhibit tumor development. |
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Animal Model: |
NCR-nu/nu female mice (6-7 week old) injected with MPNST cells |
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Dosage: |
40mg/kg |
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Administration: |
Intraperitoneal injection; twice per day for 4 weeks |
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Result: |
Reduced MPNST burden in a mouse allograft model. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )