中文名称: | SS28 | ||||
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英文名称: | SS28 | ||||
CAS No: | 141172-08-9 | 分子式: | C18H20O3 | 分子量: | 284.35 |
CAS No: | 141172-08-9 | ||||
分子式: | C18H20O3 | ||||
分子量: | 284.35 |
基本信息
产品编号:S10718 |
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产品名称:SS28 |
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CAS: |
141172-08-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量: |
284,35 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内(现配现用) |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
一种具有口服生物利用度的SRT501 类似物,可抑制微管蛋白聚合,在G2/M引起细胞周期阻滞。 |
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靶点/IC50 |
Tubulin. |
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体外研究 |
SS28 (0-20μM) induces cytotoxicity in different cancer cell lines.SS28 treatment (5μM for A549 and 2μM for CEM) results in cell cycle arrest at G2/M phase leading to apoptosis upon further incubation. Cell Proliferation Assay |
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Cell Line: |
CEM, Reh, Nalm6, SUDHL8, Molt4, A549, HeLa 293T cells. |
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Concentration: |
1, 5, 10 and 20μM. |
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Incubation Time: |
48 and 72h. |
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Result: |
CEM and A549 exhibited maximum sensitivity to SS28 followed by SUDHL8, Molt4 and Reh, whereas Nalm6 showed moderate sensitivity after 48h of the treatment.IC50 values of SS28 in CEM and A549 cell line were 2.6 and 5.2μM, respectively, whereas in SUDHL8, Molt4, Reh and Nalm6 were 2.7, 5.1, 7.9 and 21μM,respectively after 48 h of treatment |
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Cell Cycle Analysis |
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Cell Line: |
CEM and A549 cells. |
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Concentration: |
2μM (CEM) and 5μM (A549). |
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Incubation Time: |
6, 12, 18, 24 and 30h. |
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Result: |
Showed significant accumulation of cells at G2/M phase in a time-dependent manner (6 to 24h) and a subsequent increase in the sub-G1 population, indicative of apoptosis at 30h in case of A549.Similarly, studies in CEM also showed a distinct G2/M arrest after 12h of treatment, as compared to vehicle control. |
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体内研究 |
SS28 (15mg/kg. b.wt.) treatment results in inhibition of tumor cell proliferation. |
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Animal Model: |
BALB/c mice using EAC cells. |
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Dosage: |
15mg/kg. |
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Administration: |
Orally on every alternate day for 9 doses. |
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Result: |
There was no further tumor progression in the mice when SS28 was administered, unlike the untreated tumor control mice. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )