| 中文名称: | Sapanisertib（INK128 MLN0128） 促销 一键复制产品信息 | ||||
|---|---|---|---|---|---|
| 英文名称: | Sapanisertib（INK128 MLN0128） | ||||
| 别名: | 沙帕色替 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | ||||
| CAS No: | 1224844-38-5 | 分子式: | C15H15N7O | 分子量: | 309.33 |
| CAS No: | 1224844-38-5 | ||||
| 分子式: | C15H15N7O | ||||
| 分子量: | 309.33 | ||||
| MDL: | MFCD22124893 | ||||
包装规格：
5mg 25mg 100mg in glass bottle
产品简介：
一种TORC1/2抑制剂，IC50：1 nM。也是具有潜在抗肿瘤活性的raptor-mTOR(TOR复合体1或TORC1)和.or-mTOR(TOR复合体2或TORC2)的抑制剂。
Sapanisertib is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. TORC1/2 inhibitor INK128 binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers.
Sapanisertib is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. TORC1/2 inhibitor INK128 binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers.
溶解性：
溶于DMSO(62mg/ml at 25°C)和乙醇(2mg/ml at 25°C)
保存条件：
-20℃
UN码：
HazardClass：
危害声明：
安全说明：
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Lot/Batch Number
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
