基本信息
产品编号: |
R70023 |
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产品名称: |
L-Tetrahydropalmatine |
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CAS: |
483-14-7 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
355.40 |
-20℃ |
1个月 |
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化学名: |
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Solubility (25°C): |
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体外:
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DMSO |
71mg/mL (199.75mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.8135mL |
14.0675mL |
28.1349mL |
5mM |
0.5627mL |
2.8135mL |
5.6270mL |
10mM |
0.2813mL |
1.4067mL |
2.8135mL |
生物活性
产品描述 |
一种多巴胺 D1,D2和D3受体的拮抗剂。 |
靶点 |
5-HT Receptor;Dopamine Receptor |
体内研究 |
It is reported that Rotundine (l-THP) possesses a blocking effect on dopamine D1 and D2 receptors and can inhibit physical dependence in morphine dependent mice and significantly reduce the development of the conditional place preference induced by morphine in mice.On day 1 and 7,there is no difference in locomotor counts between the Rotundine groups (6.25,12.5, and 18.75mg/kg) and saline group [F(3,37)=1.360,P>0.05, F(3,37)=0.348,P>0.05,respectively].Locomotor counts are greatly increased in the oxycodone group compare with the saline group.Rotundine at doses of 6.25,12.5,and 18.75mg/kg antagonizes hyperactivity induced by oxycodone [F(4,60)=15.76,P<0.01].Rotundine (6.25,12.5mg/kg) does not affect the magnitude of sensitization,but there is a marked difference between oxycodone+oxycodone group and Rotundine (18.75mg/kg)+oxycodone+oxycodone group,indicating that Rotundine (18.75mg/kg) greatly inhibits the development of oxycodone sensitization [F(4,62)=8.766,P<0.01]. |
推荐实验方法(仅供参考)
动物实验: |
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Kunming mice,initially weighing 18 to 22g are used in this study.Four groups of mice are given Rotundine (l-THP) (6.25,12.5,and 18.75mg/kg) or saline,respectively,once per day for 7 consecutive days,followed by a 5 d withdrawal period.On d 13,all animals are challenged with saline. On day 1,7,and 13,after 40-min treatment with Rotundine or saline,the mice are put into the test boxes and locomotor activity is monitored for 60 min. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )