| 中文名称: | 盐酸罗哌卡因 促销 | ||||
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| 英文名称: | Ropivacaine hydrochloride monohydrate | ||||
| 别名: | (-)-S)-N-(2,6-二甲基苯基)-1-正丙基哌啶-2-甲酰胺盐酸盐一水合物 Ropivacaine hydrochloride hydrate;(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide;hydrate;hydrochloride | ||||
| CAS No: | 132112-35-7 | 分子式: | C17H26N2O2.HCl.H2O | 分子量: | 328.88 |
| CAS No: | 132112-35-7 | ||||
| 分子式: | C17H26N2O2.HCl.H2O | ||||
| 分子量: | 328.88 | ||||
| MDL: | MFCD00946578 | ||||
基本信息
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产品编号： |
R50003 |
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产品名称： |
Ropivacaine hydrochloride monohydrate |
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CAS: |
132112-35-7 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
328.88 |
-20℃ |
1个月 |
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化学名： |
(S)-ROPIVACAINE HYDROCHLORIDE;(S)-1-propyl-2',6'-dimethylanilinoformoxylpiperidine monohydrochloride monohydrate |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.0406mL |
15.2031mL |
30.4062mL |
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5mM |
0.6081mL |
3.0406mL |
6.0812mL |
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10mM |
0.3041mL |
1.5203mL |
3.0406mL |
生物活性
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产品描述 |
通过阻止神经纤维细胞膜的内向运动，使神经纤维的脉冲传播可逆地阻断神经传导。 |
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靶点 |
IC50:sodium ion influx IC50:402.7μM (TREK-1 in COS-7 cell's membrane) |
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体内研究 |
Epidural administration of Ropivacaine hydrochloride monohydrate effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury.Ropivacaine hydrochloride monohydrate inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa),pulmonary capillary pressures (Ppc),and zonal characteristics (ZC).Ropivacaine hydrochloride monohydrate prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2,lung wet-to-dry ratio and plasma volume in levels similar to sham rats.Ropivacaine hydrochloride monohydrate inhibits pressure-induced NO production as evidenced by decreased lung nitrotyrosine content when compared to hypertensive lungs. |
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Animal Model: |
Adult Sprague-Dawley rats (300–400g) |
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Dosage: |
1μM |
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Administration: |
Infusion (added to the perfusate reservoir) |
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Result: |
Attenuated pressure-dependent increases in filtration coefficient (Kf). |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
