| 中文名称: | Reversine | ||||
|---|---|---|---|---|---|
| 英文名称: | Reversine | ||||
| 别名: | 2-(4-Morpholinoanilino)-6-cyclohexylaminopurine | ||||
| CAS No: | 656820-32-5 | 分子式: | C21H27N7O | 分子量: | 393.49 |
| CAS No: | 656820-32-5 | ||||
| 分子式: | C21H27N7O | ||||
| 分子量: | 393.49 | ||||
| MDL: | MFCD07784513 | ||||
一种作用于ARK-1、ARK-2和ARK-3的ATP竞争性抑制剂。
Reversine is a cell-permeable, 2,6-disubstituted purine analog that acts as a dedifferentiation-inducing agent. Reversine is shown to induce mouse C2C12 myoblast cells to become multipotent mesenchymal progenitor cells in the concentration range of 1-10 μM. Reversine is also the first organic molecule that has been demonstrated to reverse the cellular differentiation process. The compound acts as a selective A3 adenosine receptor antagonist (Ki= 660 nM, >10 μM, and >10 μM for hA3, hA1, and hA2A, respectively. Reversine functions as a dual inhibitor of MEK1 and nonmuscle myosin II heavy chain (IC50 = 8 and 10 nM, respectively). The compound also acts as an ATP-competitive, reversible and selective inhibitor of ARK-1, ARK-2, and ARK-3 (IC50 = 400, 500 and 400 nM, respectively) in a 26-kinase panel.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
