| 中文名称: | Quinpirole Hydrochloride | ||||
|---|---|---|---|---|---|
| 英文名称: | Quinpirole Hydrochloride | ||||
| 别名: | (-)-喹吡罗盐酸盐 (-)-LY 171555;trans-(–)-(4aR)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline monohydrochloride, (–)-Quinpirole monohydrochloride | ||||
| CAS No: | 85798-08-9 | 分子式: | C13H21N3.HCl | 分子量: | 255.79 |
| CAS No: | 85798-08-9 | ||||
| 分子式: | C13H21N3.HCl | ||||
| 分子量: | 255.79 | ||||
| MDL: | MFCD00069336 | ||||
基本信息
|
产品编号： |
Q10048 |
||||
|
产品名称： |
Quinpirole Hydrochloride |
||||
|
CAS: |
85798-08-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
|
|
|
||||
|
分子式： |
溶于液体 |
-80℃ |
6个月 |
||
|
分子量： |
255.79 |
-20℃ |
1个月 |
||
|
化学名： |
(-)-LY 171555;trans-(–)-(4aR)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline monohydrochloride, (–)-Quinpirole monohydrochloride |
||||
|
Solubility (25°C)： |
|||||
|
体外:
|
DMSO |
25mg/mL (97.7364mM; Need ultrasonic) |
|||
|
Ethanol |
|
||||
|
Water |
50mg/mL (195.47mM; Need ultrasonic) |
||||
|
体内(现配现用): |
|
||||
|
＜1mg/ml表示微溶或不溶。 |
|||||
|
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
|||||
|
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
|||||
制备储备液
|
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
|
1mM |
2.7919mL |
13.9595 mL |
27.9189 mL |
|
5mM |
0.7819mL |
3.9095 mL |
7.8189 mL |
|
10mM |
3.9095mL |
19.5473 mL |
39.0946 mL |
生物活性
|
产品描述 |
一种具有高亲和力的 dopamine D2/D3 受体的激动剂。 |
|
靶点 |
Dopamine D2/D3 receptor |
|
体外研究 |
DA content is left brain biased across groups,and although this asymmetry appears greater in saline controls than all drugtreated groups, there is not a significant interaction between Side and Group.When each side is considered separately it can be seen that in the left brain structure,DA levels progressively decrease with chronic quinpirole treatment,with the QQ rats differing significantly from saline controls.In contrast,right cortical DA levels are only altered significantly (increased) by acute Quinpirole.It can be found that DOPAC levels are also left brain biased across groups.However,no significant Group or interaction effects are found.Rats receiving acute Quinpirole show a selective increase in DA content and decrease in turnover ratio, relative toeither saline controls or the QS group.Sensitized (QQ) rats however, have elevated DOPAC levels in comparison to the acute quinpirole group.In striatum as well,all three measures of DA function differed significantly across groups (DA,F3,33=6.27,P=0.0020;DOPAC, F3,33=7.98,P=0.0004;turnover ratio,F3,33=16.85,P<0.0001).In the acute quinpirole rats,both DOPAC and turnover ratio are significantly reduced relative to all other groups. In QQ rats, DOPAC levels are ignificantly greater than all other groups, while for turnover ratio, both chronic quinpirole groups were increased compared to both chronic saline groups. |
推荐实验方法(仅供参考)
|
动物实验: |
|
|
Rat 36 male Long-Evans rats are injected daily for 12 days with either saline or Quinpirole (Hydrochloride) (quinpirole HCl:0.5mg/kg,s.c.,n=18/condition),and placed immediately in Omnitech activity monitors (60×60×40 cm) for 90 min.On the final test day, half the rats in each chronic condition received saline and half Quinpirole (n=9/group).The four groups therefore represented saline controls (SS),acute Quinpirole (SQ),sensitized Quinpirole (no drug)(QS) and sensitized Quinpirole (drug) (QQ).30 min after the final injection,each rat is removed from the activity monitors to a nearby room and killed immediately by decapitation.This time point is chosen to dissociate the behavioural effects of quinpirole between groups,since acute quinpirole produces inhibition of activity at this time, while chronic quinpirole is associated with pronounced hyperlocomotion at 30 min. |
|
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
