| 中文名称: | 4-P-PDOT | ||||
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| 英文名称: | 4-P-PDOT | ||||
| 别名: | N-(4-苯基-1,2,3,4-四氢萘-2-基)丙酰胺 N-(4-Phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide | ||||
| CAS No: | 134865-74-0 | 分子式: | C19H21NO | 分子量: | 279.38 |
| CAS No: | 134865-74-0 | ||||
| 分子式: | C19H21NO | ||||
| 分子量: | 279.38 | ||||
基本信息
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产品编号： |
P70121 |
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产品名称： |
4-P-PDOT |
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CAS: |
134865-74-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
279.38 |
-20℃ |
1个月 |
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化学名： |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.5794mL |
17.8968mL |
35.7935mL |
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5mM |
0.7159mL |
3.5794mL |
7.1587mL |
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10mM |
0.3579mL |
1.7897mL |
3.5794mL |
生物活性
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产品描述 |
一种有效的，选择性的和亲和性的褪黑激素受体 (MT2) 拮抗剂。 |
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靶点 |
MT2 receptor |
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体外研究 |
In CHO-mt1 cells the amidotetraline 4-P-PDOT (10mM) has no effect on forskolin-stimulated cyclic AMP levels,either alone,or in the presence of Melatonin.In contrast,in CHO-MT2 cells,4-P-PDOT is an agonist, producing a concentration-dependent inhibition of forskolin stimulated cyclic AMP,with a pEC50 value of 8.72 and intrinsic activity of 0.86. Cell Viability Assay |
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Cell Line: |
HT-29 and HeLa cells. |
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Concentration: |
30 min. |
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Incubation Time: |
50µM. |
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Result: |
Produced a negligible effect on cell viability induced by melatonin. |
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体内研究 |
4-P-PDOT (0.5-1.0mg/kg;intravenous injection;klotho mutant mice) treatment significantly reverses antioxidant effects mediated by Melatonin.And significantly reverses the changes in the levels of these GSH-related parameters.4-P-PDOT treatment significantly reverses the memory function of Melatonin-treated klotho mutant mice.4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression,Nrf2 nuclear translocation,Nrf2 DNA-binding activity,and GCL mRNA expression in the hippocampi of klotho mutant mice. |
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Animal Model: |
Klotho mutant mice treatment with Melatonin |
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Dosage: |
0.5mg/kg or 1.0mg/kg |
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Administration: |
Intravenous injection |
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Result: |
Significantly reversed antioxidant effects mediated by Melatonin.Significantly reversed the changes in the levels of these GSH-related parameters.Significantly reversed the memory function of Melatonin-treated klotho mutant mice. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
