基本信息
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产品编号： |
P50032 |
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产品名称： |
Pentanoic acid |
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CAS: |
109-52-4 |
储存条件 |
粉末 |
室温 |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
102.13 |
-20℃ |
1个月 |
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化学名： |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
9.7914mL |
48.9572mL |
97.9144mL |
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5mM |
1.9583mL |
9.7914mL |
19.5829mL |
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10mM |
0.9791mL |
4.8957mL |
9.7914mL |
生物活性
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产品描述 |
一种短链脂肪酸，是细菌代谢产物，与过敏性皮肤病有关系。Pentanoic acid 能够激活ROCK信号通路。 |
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靶点 |
Human Endogenous Metabolite |
ROCK |
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体外研究 |
Pentanoic acid,a short-chain fatty acid,is a product of bacterial metabolism and are associated with allergic skin disorders.Pentanoic acid (0-2mM) strongly and dose-dependently induces thymic stromal lymphopoietin (TSLP) production in PAM212 cells.Pentanoic acid slightly induces the expression of Tnfa,Il1b and Il6 mRNA, but does not induce the protein levels of TNF-α expression.Pentanoic acid (2mM) induced-TSLP production in keratinocytes is not related to FFAR2 and FFAR3,but mediated by activating ROCK signaling pathway,and is competetely inhibited by co-inhibition of Gq/11 and the ROCK signaling pathway. |
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推荐实验方法(仅供参考)
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细胞实验: |
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PAM212 murine keratinocytes are derived from BALB/c mouse skin.PAM212 cells are cultured in alpha minimal essential medium containing 10% heat-inactivated fetal bovine serum,penicillin G (15μg/mL),and streptomycin (50μg/mL) in a humidified atmosphere of 5% CO2/95% air at 37℃.Cells seeded at 50,000 cells/mL are grown for 24h in culture medium.Cells are stimulated with Pentanoic acid for an appropriate period.Pretreatment with Y-27632,a highly potent and selective inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK),is carried out for 1h,whereas pretreatment with YM-254890,a specific Gq/11 inhibitor, is carried out for 30 min. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
