中文名称: | PD-161570 | ||||
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英文名称: | PD-161570 | ||||
别名: | PD-161570 PD-161570 | ||||
CAS No: | 192705-80-9 | 分子式: | C26H35Cl2N7O | 分子量: | 532.51 |
CAS No: | 192705-80-9 | ||||
分子式: | C26H35Cl2N7O | ||||
分子量: | 532.51 |
基本信息
产品编号:P11676 |
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产品名称:PD-161570 |
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CAS: |
192705-80-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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|
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分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
532.51 |
-20℃ |
一个月 |
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化学名: |
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制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
1.8779mL |
9.3895mL |
18.7790mL |
5mM |
0.3756mL |
1.8779mL |
3.7558mL |
10mM |
0.1878mL |
0.9389mL |
1.8779mL |
生物活性
产品描述 |
一种有效的且具有ATP竞争能力的人FGF-1受体抑制剂,还抑制PDGFR,EGFR和c-Src酪氨酸激酶,抑制PDGF刺激的自磷酸化和FGF-1受体磷酸化,还是一种骨形态发生蛋白(BMPs)和TGF-β信号抑制剂。 |
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靶点/IC50 |
FGFR1 39.9nM (IC50) |
FGFR1 42nM (Ki) |
FGFR1 autophosphorylation 622nM (IC50) |
PDGFRβ 262nM (IC50) |
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PDGFR 310nM (IC50) |
EGFR 240nM (IC50) |
c-Src 44nM (IC50) |
TGF-β Receptor |
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体外研究 |
PD-161570 (Compound 6c; 0.1-1µM; 1-8 days; VSMCs) treatment inhibits PDGF-stimulated vascular smooth muscle cellproliferation in a dose dependent fashion with an IC50 of 0.3µM on day 8. PD-161570 suppresses constitutive phosphorylation of the FGF-1 receptor in both human ovarian carcinoma cells (A121(p)) and Sf9 insect cells overexpressing the human FGF-1 receptor and blocked the growth of A121(p) cells in culture. PD-161570 can potently inhibit basic fibroblast growth factor (bFGF)-mediated angiogenesis. Cell Proliferation Assay |
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Cell Line: |
Vascular smooth muscles cells (VSMCs) |
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Concentration: |
0.1µM, 0.3µM, 1µM |
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Incubation Time: |
1 day, 3 days, 6 days, 8 days |
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Result: |
Inhibited VSMC proliferation in a dose dependent fashion with an IC50 of 0.3µM at day 8. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )