| 中文名称: | PD-089828 | ||||
|---|---|---|---|---|---|
| 英文名称: | PD-089828 | ||||
| 别名: | PD-089828 PD-089828 | ||||
| CAS No: | 179343-17-0 | 分子式: | C18H18Cl2N6O | 分子量: | 405.28 |
| CAS No: | 179343-17-0 | ||||
| 分子式: | C18H18Cl2N6O | ||||
| 分子量: | 405.28 | ||||
一种ATP竞争性FGFR-1、PDGFR-β和EGFR(IC50分别为0.15,1.76,5.47µM)抑制剂和c-Src酪氨酸激酶非竞争性抑制剂(IC50=0.18µM).也抑制MAPK，IC50值为7.1µM。PD-089828体外抑制PDGF-、EGF-和bFGF介导的酪氨酸激酶受体的自磷酸化。PD-089828具有持久的细胞活性。
PD089828 is a potent FGFR inhibitor, which inhibits human full-length fibroblast growth factor (FGF) receptor-1 (FGFR-1), platelet-derived growth factor (PDGF) receptor beta subunit (PDGFR-beta), Src nonreceptor tyrosine kinase (c-Src) and epidermal growth factor (EGF) receptor (EGFR) tyrosine kinases with half-maximal inhibitory potencies (IC50 values) of 0.15 +/- 0.02 (n = 4), 0.18 +/- 0.04 (n = 3), 1.76 +/- 0.28 (n = 4) and 5.47 +/- 0.78 (n = 6) microM, respectively. The results highlight the biological characteristics of PD 089828 as a novel, broadly active protein tyrosine kinase inhibitor with long-lasting but reversible cellular effects. The potential therapeutic use of these broadly acting, nonselective inhibitors as antiproliferative and antimigratory agents could extend to such diseases as cancer, atherosclerosis and restenosis in which redundancies in growth-signaling pathways are known to exist.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
