| 中文名称: | PF-06840003 促销 | ||||
|---|---|---|---|---|---|
| 英文名称: | PF-06840003 | ||||
| 别名: | 3-(5-氟-1H-吲哚-3-基)-2,5-吡咯烷二酮 EOS200271;3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione | ||||
| CAS No: | 198474-05-4 | 分子式: | C12H9FN2O2 | 分子量: | 232.21 |
| CAS No: | 198474-05-4 | ||||
| 分子式: | C12H9FN2O2 | ||||
| 分子量: | 232.21 | ||||
一种有口服活性的 选择性 IDO-1 抑制剂。
PF-06840003, also known as EOS200271, is potent IDO-1 inhibitor (IC50 0.15 μM). PF-0684000 has moderate hIDO1 enzyme inhibition (IC50 0.41 μM). It is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size. PF-0684000 shows good potency in an IDO-1 human whole blood assay and also shows a very favorable ADME profile leading to favorable predicted human pharmacokinetic properties, including a predicted half-life of 16−19 h.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
