| 中文名称: | (2R/S)-6-PNG | ||||
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| 英文名称: | (2R/S)-6-PNG | ||||
| 别名: | (2R/S)-6-PNG 6-Prenylnaringenin;6PNG | ||||
| CAS No: | 68682-01-9 | 分子式: | C20H20O5 | 分子量: | 340.37 |
| CAS No: | 68682-01-9 | ||||
| 分子式: | C20H20O5 | ||||
| 分子量: | 340.37 | ||||
基本信息
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产品编号： |
P11255 |
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产品名称： |
(2R/S)-6-PNG |
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CAS: |
68682-01-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
340.37 |
-20℃ |
1个月 |
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化学名： |
5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种T型Ca2+通道(Cav3.2)阻滞剂。(2R/S)-6-PNG抑制小鼠疼痛模型中的神经性异常性疼痛。 |
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靶点 |
Cav3.2 |
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体外研究 |
(2R/S)-6-PNG (6-Prenylnaringenin) potently blocks Cav3.2,but exhibits minor effect on high-voltage-activated Ca2+channels and voltage-gated Na+channels in differentiated NG108-15 cells.On the basis of IC50 values,the proportion (Cav3.2/HVA) of the inhibition potency of (2R/S)-6-PNG on Cav3.2 and HVAcurrents is 5.20,and that (Cav3.2/Nav) on Cav3.2 and Nav-currents is 3.54. |
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体内研究 |
(2R/S)-6-PNG (6-Prenylnaringenin;10-30mg/kg;i.p.;single dose;15 min before Na2S) significantly reduced the Na2Sinduced nociceptive behavior and/or referred hyperalgesia in onscious mice with intracolonic (i.col.) administration of Na2S,an H2S donor.(2R/S)-6-PNG (30mg/kg;i.p.) prevents the increased number of phosphorylated ERK-positive cells following i.col.Na2S in laminae I-II,V-VI and X to which the primary afferent neurons project,and the Na2S-induced increase in the phosphorylated ERK-positive cell number.(2R/S)-6-PNG (0.01-1 and 0.1-10nmol/paw;intraplantar administration) restores the mechanical allodynia induced by partial sciatic nerve ligation (PSNL) and by i.p.administration of Oxaliplatin (OHP) a,respectively,in a dose-dependent manner.(2R/S)-6-PNG (20-30mg/kg;i.p.) significantly reverses the PSNL-induced allodynia.(2R/S)-6-PNG (10-20mg/kg;i.p.) significantly reverses the OHP-induced allodynia (5mg/kg;i.p.;single dose). |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
