中文名称: | (+)-PD 128907 hydrochloride | ||||
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英文名称: | (+)-PD 128907 hydrochloride | ||||
别名: | (+)-PD 128907 盐酸盐;(4aR,10aR)-1-丙基-2,3,10,10a-四氢-1H,4aH-4,9-二氧杂-1-氮杂菲-6-醇盐酸盐;(4AR,10AR)-1-丙基-2,3,10,10A-四氢-1H,4AH-4,9-二氧杂-1-氮杂菲-6-醇盐酸盐;PD 128907盐酸盐;(+)-PD 128907, 盐酸盐 (+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride | ||||
CAS No: | 300576-59-4 | 分子式: | C14H19NO3.HCl | 分子量: | 285.77 |
CAS No: | 300576-59-4 | ||||
分子式: | C14H19NO3.HCl | ||||
分子量: | 285.77 | ||||
MDL: | MFCD00210210 |
基本信息
产品编号: |
P11015 |
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产品名称: |
(+)-PD 128907 hydrochloride |
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CAS: |
300576-59-4 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
285.77 |
-20℃ |
1个月 |
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化学名: |
(+)-PD 128907,盐酸盐(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.4993mL |
17.4966mL |
34.9932mL |
5mM |
0.6999mL |
3.4993mL |
6.9986mL |
10mM |
0.3499mL |
1.7497mL |
3.4993mL |
生物活性
产品描述 |
一种多巴胺D2/D3 受体的选择性激动剂,其在人类和大鼠中对D3 的 Ki 值分别为0.7,0.84nM,对D2 的Ki 值分别为179,770nM。 |
靶点 |
Ki:1.7nM (human D3 receptor),0.84nM (rat D3 receptor),179nM (human D2 receptor),770nM (rat D2 receptor). |
体外研究 |
(+)-PD 128907 displaced [3H]spiperone binding from dopamine D3 receptors (Ki human=1.7nM and rat=0.84nM) with>100-fold and 900-fold selectivity over the human (Ki=179nM) and rat (Ki=770nM) dopamine D2 receptor. |
体内研究 |
(+)-PD 128907 significantly decreases dialysate DA levels in D3 knock out mice.The IC25 values are 61nM and 1327nM,respectively, for wild type and D3knock out mice. The ratio of the IC25 values shows that (+)-PD 128907 is 22 times more potent in decreasing dialysate DA levels in wild type as compared to mice lacking the D3 receptor.The D3 agonist evokes a dose related decrease in dialysate DA in wild type mice.Post-hoc analysis shows that all doses tested (0.03,0.1 and 0.3mg/kg) significantly inhibit dialysate DA.The IC25 values are 0.05 and 0.44mg/kg for wild type and knock out mice,respectively,indicating that systemically administered (+)-PD 128907 is 9 times more potent in decreasing dialysate DA in the ventral striatum of wild type as compared to D3 knock out mice.Doses of 1mg/kg or higher of (+)-PD 128907 markedly inhibits dialysate DA in both wild type and D3 knock out mice. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )